Journal article
DEVELOPMENTAL ASPECTS OF THE FETAL RENAL RESPONSE TO EXOGENOUS ARGININE VASOPRESSIN
The American journal of physiology, Vol.238(5), pp.F407-F414
05/1980
DOI: 10.1152/ajprenal.1980.238.5.F407
PMID: 6990788
Abstract
Response of the fetal kidney to infusion of exogenous arginine vasopressin [AVP] (600 .mu.U/min per kg fetal body weight) was studied in 19 chronically catheterized fetuses between 106 and 142 days of gestation (term 145 days). In all fetuses over 112 days of gestation, the presence of free water reabsorption was demonstrated during AVP infusion. In fetuses 112 days or less, it was not possible to determine whether the decrease in free water clearance values found during AVP infusion was secondary to the action of AVP alone or to an osmotic diuresis secondary to AVP infusion. To further assess the sensitivity of the fetal kidney to AVP, urine osmolality (Uosmol) was determined at different levels of plasma AVP (PAVP) concentration. Maximum Uosmol was reached at PAVP levels between 5 and 6 .mu.U/ml. The slope of the regression line between fetal lamb PAVP and Uosmol (35) for PAVP levels below 6 .mu.U/ml was less steep than in adult dogs (200). The AVP plasma clearance rate (PCRAVP) was measured in 10 fetuses to assess if the fetal renal response to AVP might be dependent on the possible maturation of the metabolic handling of AVP. The mean PCRAVP value was 50.4 .+-. 3.40 ml/min and did not correlate with either fetal age or body weight. Apparently fetal kidney is sensitive to vasopressin during the last part of gestation. Because the slope of the regression line between fetal PAVP and Uosmol is less steep than in adults, it is speculated that the AVP receptors are still not fully functional.
Details
- Title: Subtitle
- DEVELOPMENTAL ASPECTS OF THE FETAL RENAL RESPONSE TO EXOGENOUS ARGININE VASOPRESSIN
- Creators
- Jean E RobillardRichard E Weitzman
- Resource Type
- Journal article
- Publication Details
- The American journal of physiology, Vol.238(5), pp.F407-F414
- DOI
- 10.1152/ajprenal.1980.238.5.F407
- PMID
- 6990788
- NLM abbreviation
- Am J Physiol
- ISSN
- 0002-9513
- eISSN
- 1522-1466
- Publisher
- Amer Physiological Soc
- Number of pages
- 8
- Language
- English
- Date published
- 05/1980
- Academic Unit
- Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Medicine Administration
- Record Identifier
- 9984773403102771
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