Journal article
DEVELOPMENTAL CHANGES IN THE EXPRESSION AND DISTRIBUTION OF CELLULAR RETINOIC ACID BINDING PROTEIN (CRABP) IN THE CENTRAL NERVOUS SYSTEM OF THE CHICK EMBRYO
Biomedical research (Tokyo), Vol.10(1), pp.43-48
1989
DOI: 10.2220/biomedres.10.43
Abstract
A large amount of cellular retinoic acid binding protein (CRABP), by which the action ofretinoic acid is mediated, was present in the central nervous system as well as limb buds in the early developmental stages of chick embryo. The expression of CRABP in the brain was developmentally changed. The highest level of CRABP expression occurred during stages 22-28 and it gradually disappeared thereafter. By stages 38-43, CRABP was not detected in the brain. At stage 25, CRABP was intensely expressed on both sides of the neural tubes where neuroblast cells proliferate and differentiate. The localization and the expression of CRABP in the central nervous system in the early developmental stages of chick embryo suggest the possibility that retinoic acid is involved in the differentiation and growth of neuronal
cells during the development.
Details
- Title: Subtitle
- DEVELOPMENTAL CHANGES IN THE EXPRESSION AND DISTRIBUTION OF CELLULAR RETINOIC ACID BINDING PROTEIN (CRABP) IN THE CENTRAL NERVOUS SYSTEM OF THE CHICK EMBRYO
- Creators
- TAKASHI MOMOI - National Institute of Neuroscience, NCNPTOSHIHIRO KITAMOTO - University of Iowa, AnesthesiaJUNKO KASUYA-SATO - National Institute of Neuroscience, NCNPHARUKI SENO - Department of Anatomy, Faculty of Medicine, Tokyo Medical and Dental UniversityMARIKO MOMOI - Department of Pediatrics, Jichi Medical School
- Resource Type
- Journal article
- Publication Details
- Biomedical research (Tokyo), Vol.10(1), pp.43-48
- DOI
- 10.2220/biomedres.10.43
- ISSN
- 0388-6107
- eISSN
- 1880-313X
- Language
- English
- Date published
- 1989
- Academic Unit
- Neuroscience and Pharmacology; Iowa Neuroscience Institute; Anesthesia
- Record Identifier
- 9984071994802771
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