DM-GRASP, a novel immunoglobulin superfamily axonal surface protein that supports neurite extension

Frank R Burns; Stephanie von Kannen; Leslie Guy; Jonathan A Raper; John Kamholz; Susannah Chang

doi:10.1016/0896-6273(91)90259-3

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DM-GRASP, a novel immunoglobulin superfamily axonal surface protein that supports neurite extension

Journal article

Peer reviewed

DM-GRASP, a novel immunoglobulin superfamily axonal surface protein that supports neurite extension

Frank R Burns, Stephanie von Kannen, Leslie Guy, Jonathan A Raper, John Kamholz and Susannah Chang

Neuron (Cambridge, Mass.), Vol.7(2), pp.209-220

1991

DOI: 10.1016/0896-6273(91)90259-3

PMID: 1873027

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Abstract

We have identified a 95 kd cell surface protein, DM-GRASP, that is expressed on a restricted population of axons. Its expression begins early in chick embryogenesis, and within the spinal cord it is localized to axons in the dorsal funiculus, midline floorplate cells, and motorneurons. Antibodies to DM-GRASP impair neurite extension on axons, and purified DM-GRASP supports neurite extension from chick sensory neurons. We have cloned and sequenced the cDNA corresponding to this protein and find that it is a new member of the immunoglobulin superfamily of adhesion molecules. Consequently we have named this protein DM-GRASP, since it is an immunoglobulin-like restricted axonal surface protein that is expressed in the dorsal funiculus and ventral midline of the chick spinal cord.

Details

Title: Subtitle: DM-GRASP, a novel immunoglobulin superfamily axonal surface protein that supports neurite extension
Creators: Frank R Burns - Department of Neurology University of Pennsylvania School of Medicine Philadelphia, Pennsylvania 19104, USA
Stephanie von Kannen - Department of Anatomy University of Pennsylvania School of Medicine Philadelphia, Pennsylvania 19104, USA
Leslie Guy - Department of Anatomy University of Pennsylvania School of Medicine Philadelphia, Pennsylvania 19104, USA
Jonathan A Raper - Department of Anatomy University of Pennsylvania School of Medicine Philadelphia, Pennsylvania 19104, USA
John Kamholz - Department of Neurology University of Pennsylvania School of Medicine Philadelphia, Pennsylvania 19104, USA
Susannah Chang - Department of Anatomy University of Pennsylvania School of Medicine Philadelphia, Pennsylvania 19104, USA
Resource Type: Journal article
Publication Details: Neuron (Cambridge, Mass.), Vol.7(2), pp.209-220
DOI: 10.1016/0896-6273(91)90259-3
PMID: 1873027
NLM abbreviation: Neuron
ISSN: 0896-6273
eISSN: 1097-4199
Publisher: Elsevier Inc
Language: English
Date published: 1991
Academic Unit: Neurology; Psychiatry
Record Identifier: 9984020859702771

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