Journal article
DNA damage associated with PCBs in the whole blood cells of Inuit
Environmental toxicology and pharmacology, Vol.25(2), pp.273-276
2008
DOI: 10.1016/j.etap.2007.10.027
PMID: 21783863
Abstract
Lower chlorinated PCBs can damage DNA directly or via free radical mechanisms. In order to assess the DNA-damaging potential of PCBs in humans, blood samples were collected from Inuit population from Salluit, Northern Canada. Their diet comprises blubber from sea mammals and fatty fish, which accumulate non-biodegradable PCBs at varying levels. The 103 samples thus collected were categorized into low-, medium- and high-PCB exposure groups. A comprehensive
32P-postlabeling adductomics technology, which allows measure differences in DNA adduct profiles of polar and lipophilic adducts between control and exposure groups, was applied to these samples to assess the effect of PCB on DNA damage. The adduct patterns obtained were qualitatively similar to other human tissues studied previously. A range of highly polar to lipophilic subgroups of adducts were detected. The known oxidative lesion, 8-oxodG was predominant. While some individual adducts appear to accumulate with increasing PCB levels, a definitive association could not be made. A possible confounder effect of selenium is discussed.
Details
- Title: Subtitle
- DNA damage associated with PCBs in the whole blood cells of Inuit
- Creators
- Srivani Ravoori - James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USAPierre Ayotte - Laval University Medical Research Center, Quebec, QC G1V 5B3, CanadaCidambi Srinivasan - Department of Statistics, University of Kentucky, Lexington, KY 40506, USADaria Pereg - Laval University Medical Research Center, Quebec, QC G1V 5B3, CanadaLarry W Robertson - University of Iowa, Iowa City, IA 52242, USAGilandra K Russell - James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USAJeyaprakash Jeyabalan - James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USARamesh C Gupta - James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
- Resource Type
- Journal article
- Publication Details
- Environmental toxicology and pharmacology, Vol.25(2), pp.273-276
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.etap.2007.10.027
- PMID
- 21783863
- ISSN
- 1382-6689
- eISSN
- 1872-7077
- Language
- English
- Date published
- 2008
- Academic Unit
- Occupational and Environmental Health; Iowa Superfund Research Program
- Record Identifier
- 9984002327802771
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