DNA immunomodulation of asthma

Joel N Kline; Zuhair K Ballas

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Journal article

DNA immunomodulation of asthma

Joel N Kline and Zuhair K Ballas

Clinical allergy and immunology, Vol.16, pp.551-564

2002

PMID: 11577559

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Abstract

This is an exciting time in the chronology of asthma and allergic diseases. Although the pharmacopeia for treatment of these diseases has advanced greatly, most of our current therapies are aimed at the symptoms, rather than the underlying mechanism. Immunotherapy remains the only therapeutic modality that addresses the underlying mechanism, albeit by effects are still not fully understood. The approaches summarized in this chapter, alone or in combination, may yet allow one to reverse the atopic state. Meanwhile, other innovative DNA-based approaches are being developed, including the use of allergen DNA with or without CpG. Because most of the Th2 cytokines are on chromosome 5, the completion of the human genome project may open whole new venues of research aimed at controlling these cytokines at the chromosomal level.

DNA

Bronchial Hyperreactivity - therapy

Bronchial Hyperreactivity - immunology

Hypersensitivity - therapy

Adjuvants, Immunologic

Humans

Mice, Inbred C57BL

Hypersensitivity - immunology

Animals

Asthma - immunology

CpG Islands

Asthma - therapy

Mice

Mice, Inbred BALB C

Cytokines - genetics

Cytokines - immunology

Genetic Therapy - methods

Details

Title: Subtitle: DNA immunomodulation of asthma
Creators: Joel N Kline - University of Iowa College of Medicine, Iowa City, Iowa, USA
Zuhair K Ballas
Resource Type: Journal article
Publication Details: Clinical allergy and immunology, Vol.16, pp.551-564
PMID: 11577559
ISSN: 1075-7910
eISSN: 2372-0441
Language: English
Date published: 2002
Academic Unit: Pulmonary, Critical Care, and Occupational Medicine; Occupational and Environmental Health; Immunology; Internal Medicine
Record Identifier: 9984094708002771

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