Journal article
DNA methylation in former extremely low birth weight newborns: association with cardiovascular and endocrine function
Pediatric research, Vol.91(6), pp.1469-1477
05/2022
DOI: 10.1038/s41390-021-01531-5
PMCID: PMC8568736
PMID: 33953357
Abstract
There is increased risk of cardiovascular, metabolic, and hypertensive disorders in later life in the preterm population. We studied school-age children who had been born extremely premature who had undergone endocrine, cardiovascular, and anthropometric evaluations.
School age measurements of salivary cortisol, adrenal androgens, blood pressure, and anthropometric markers were correlated with DNA methylation of 11-betahydroxysteroid dehydrogenase type 2 (11BHSD2), leptin, and the LINE1 repetitive DNA element.
We observed a modest correlation between log AUC for salivary cortisol and methylation of leptin in preterm infants and a negative correlation between methylation of region 1 of the glucocorticoid receptor (GR in term-born infants. There was an association between LINE1 methylation and cortisol response to awakening and a negative correlation between LINE1 and systolic blood pressure at 6-7 years. Methylation of the GR promoter region showed a positive association with systolic blood pressure at 6-7 years of age.
These results show that extremely preterm birth, followed by complex patterns of endocrine, cardiovascular, and metabolic exposures during early postnatal life, is associated with lasting changes in DNA methylation patterns in genes involved in hypothalamic pituitary adrenal axis function, adrenal hormonal regulation, and cardiometabolic risk.
Preterm infants have significant environmental and physiological exposures during early life that may have lasting impact on later function. Alterations in hypothalamic pituitary adrenal axis (HPA) function have been associated with these exposures. We examined the associated changes in DNA methylation of important genes involved in HPA function, metabolism, and global DNA methylation. The changes we saw in DNA methylation may help to explain associated cardiovascular, metabolic, and growth disturbance in these children in later life.
Details
- Title: Subtitle
- DNA methylation in former extremely low birth weight newborns: association with cardiovascular and endocrine function
- Creators
- James F Padbury - Brown UniversityBarbara T Do - RTI InternationalCarla M Bann - RTI InternationalCarmen Marsit - Emory UniversitySusan R Hintz - Lucile Packard Children's HospitalBetty R Vohr - Women & Infants Hospital of Rhode IslandJean Lowe - University of New MexicoJamie E Newman - RTI InternationalDouglas A Granger - University of California, IrvineAllison Payne - Case Western Reserve UniversityKristi Watterberg - University of New MexicoSUPPORT Study Group of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
- Contributors
- Edward F Bell (Contributor) - University of Iowa, Neonatology
- Resource Type
- Journal article
- Publication Details
- Pediatric research, Vol.91(6), pp.1469-1477
- DOI
- 10.1038/s41390-021-01531-5
- PMID
- 33953357
- PMCID
- PMC8568736
- NLM abbreviation
- Pediatr Res
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- Grant note
- R01 HL117764 / NHLBI NIH HHS U10 HD021373 / NICHD NIH HHS UG1 HD053089 / NICHD NIH HHS UG1 HD087226 / NICHD NIH HHS P30 GM114750 / NIGMS NIH HHS UG1 HD027904 / NICHD NIH HHS U24 HD095254 / NICHD NIH HHS P30 GM103410 / NIGMS NIH HHS P20 RR018728 / NCRR NIH HHS UG1 HD087229 / NICHD NIH HHS P20 GM103537 / NIGMS NIH HHS U10 HD027904 / NICHD NIH HHS
- Language
- English
- Date published
- 05/2022
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984353945402771
Metrics
17 Record Views