Journal article
DNA methylation in the TNF-alpha gene decreases along with aging among delirium inpatients
Neurobiology of aging, Vol.105, pp.310-317
05/2021
DOI: 10.1016/j.neurobiolaging.2021.05.005
Abstract
It has been suggested that aging and inflammation play key roles in the development of delirium. In the present study, we investigated the differences of the DNAm patterns in the TNF gene between patients with delirium and without. The data and samples derived from previous and ongoing cohort studies were analyzed. DNAm levels of the TNF gene were analyzed using the Illumina EPIC array genome-wide method and pyrosequencing method. Correlations between age and DNAm levels of each CpG were calculated. Several CpG in the TNF gene in blood showed negative correlation between their DNAm and age in delirium cases both with the EPIC array and by the pyrosequencing method. However, there was no CpG that had significant correlation between their DNAm and age regardless of delirium status among buccal samples. On the other hand, among peripheral blood mononuclear cells samples, it was found that several CpG showed negative correlation between their DNAm and age in delirium cases. The evidence of DNAm change in the TNF gene among delirious subjects was demonstrated.
Details
- Title: Subtitle
- DNA methylation in the TNF-alpha gene decreases along with aging among delirium inpatients
- Creators
- Takehiko YamanashiTaku SaitoTong YuAlexandra AlarioKatie CompKaitlyn J CrutchleyEleanor J SullivanZoe-Ella M AndersonPedro S MarraGloria ChangNadia E WahbaSydney S JellisonAlissa A MeyerSrishti MathurPratik PandharipandeAihide YoshinoKoichi KanekoSangil LeeHiroyuki TodaMasaaki IwataGen Shinozaki
- Resource Type
- Journal article
- Publication Details
- Neurobiology of aging, Vol.105, pp.310-317
- DOI
- 10.1016/j.neurobiolaging.2021.05.005
- ISSN
- 0197-4580
- eISSN
- 1558-1497
- Language
- English
- Date published
- 05/2021
- Academic Unit
- Psychiatry; Emergency Medicine; Iowa Neuroscience Institute; Anesthesia; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9984080409902771
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