Journal article
DNA methylation markers predict recurrence-free interval in triple-negative breast cancer
NPJ breast cancer, Vol.6(1), pp.3-3
12/01/2020
DOI: 10.1038/s41523-020-0145-3
PMCID: PMC6994477
PMID: 32025567
Abstract
We lack tools to risk-stratify triple-negative breast cancer (TNBC). Our goal was to develop molecular tools to predict disease recurrence. Methylation array analysis was performed on 110 samples treated by locoregional therapy obtained from institutional cohorts. Discovered marker sets were then tested by Kaplan−Meier analyses in a prospectively collected TNBC cohort of 49 samples from the no-chemotherapy arms of IBCSG trials VIII and IX, and by logistic regression in a chemotherapy-treated cohort of 121 TNBCs from combined IBCSG trials and institutional repositories. High methylation was associated with shorter recurrence-free interval in the no-chemotherapy arm of the IBCSG studies, as well as in the chemotherapy-treated patients within the combined institutional and IBCSG chemotherapy cohorts (100 marker panel,
p
= 0.002; 30 marker panel,
p
= 0.05). Chromosome 19 sites were enriched among these loci. In conclusion, our hypermethylation signatures identify increased recurrence risk independent of whether patients receive chemotherapy.
Details
- Title: Subtitle
- DNA methylation markers predict recurrence-free interval in triple-negative breast cancer
- Creators
- Mary Jo Fackler - Baltimore, MD 21205 USASoonweng Cho - Baltimore, MD 21205 USA Baltimore, MD 21205 USALeslie Cope - Baltimore, MD 21205 USAEdward Gabrielson - Baltimore, MD 21205 USAKala Visvanathan - Baltimore, MD 21205 USA Baltimore, MD 21205 USAKathleen Wilsbach - Baltimore, MD 21205 USA Baltimore, MD 21205 USADanielle Meir-Levi - Baltimore, MD 21205 USACharles F Lynch - SEER Tissue Repository Program, State Health Registry of Iowa, Iowa City, IA 52242 USAJeffrey Marks - Durham, NC 27710 USAJoseph Geradts - Durham, NC 27710 USA Duarte, CA 91010 USAMeredith M Regan - Boston, MA 02215 USAGiuseppe Viale - Milan, ItalyAntonio C Wolff - Baltimore, MD 21205 USASaraswati Sukumar - Baltimore, MD 21205 USA Baltimore, MD 21205 USAChristopher B Umbricht - Baltimore, MD 21205 USA Baltimore, MD 21205 USA Baltimore, MD 21205 USA
- Resource Type
- Journal article
- Publication Details
- NPJ breast cancer, Vol.6(1), pp.3-3
- DOI
- 10.1038/s41523-020-0145-3
- PMID
- 32025567
- PMCID
- PMC6994477
- NLM abbreviation
- NPJ Breast Cancer
- ISSN
- 2374-4677
- eISSN
- 2374-4677
- Publisher
- Nature Publishing Group UK
- Grant note
- ; KG110094 / ;
- Language
- English
- Date published
- 12/01/2020
- Academic Unit
- Epidemiology
- Record Identifier
- 9984214856102771
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