Journal article
Daclatasvir and asunaprevir for recurrent hepatitis C following living donor liver transplantation with HIV co‐infection
Hepatology research, Vol.46(8), pp.829-832
07/2016
DOI: 10.1111/hepr.12614
PMID: 26508337
Abstract
Antiviral treatment in liver transplant recipients co‐infected with hepatitis C virus (HCV) and HIV remains a challenge. We herein report a case of HCV recurrence that was successfully treated using interferon‐free anti‐HCV therapy with daclatasvir and asunaprevir. A 48‐year‐old man underwent antiviral therapy with a 24‐week course of daclatasvir and asunaprevir for biopsy‐proven recurrent HCV 15 months after living donor liver transplantation, following non‐response to pre‐emptive antiviral treatment with pegylated interferon plus ribavirin. Anti‐HIV and immunosuppressive regimens were modified safely. Renal function was feasibly preserved. The anti‐HCV effect was remarkable with an undetectable viral load confirmed within 2 weeks, and this patient achieved a sustained virological response after 12 weeks of post‐transplantation treatment. No serious adverse events were observed. This case indicates that daclatasvir and asunaprevir for recurrent HCV in a HIV co‐infected recipient after liver transplantation is safe and effective.
Details
- Title: Subtitle
- Daclatasvir and asunaprevir for recurrent hepatitis C following living donor liver transplantation with HIV co‐infection
- Creators
- Tomohiro Tanaka - Graduate School of Medicine, The University of TokyoNobuhisa Akamatsu - Graduate School of Medicine, The University of TokyoJunichi Kaneko - Graduate School of Medicine, The University of TokyoJunichi Arita - Graduate School of Medicine, The University of TokyoSumihito Tamura - Graduate School of Medicine, The University of TokyoKiyoshi Hasegawa - Graduate School of Medicine, The University of TokyoYoshihiro Sakamoto - Graduate School of Medicine, The University of TokyoNorihiro Kokudo - Graduate School of Medicine, The University of Tokyo
- Resource Type
- Journal article
- Publication Details
- Hepatology research, Vol.46(8), pp.829-832
- DOI
- 10.1111/hepr.12614
- PMID
- 26508337
- ISSN
- 1386-6346
- eISSN
- 1872-034X
- Number of pages
- 4
- Language
- English
- Date published
- 07/2016
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984094361002771
Metrics
23 Record Views