Journal article
Daily walking and the risk of incident functional limitation in knee osteoarthritis: an observational study
Arthritis care & research (2010), Vol.66(9), pp.1328-1336
09/2014
DOI: 10.1002/acr.22362
PMCID: PMC4146701
PMID: 24923633
Abstract
Physical activity is recommended to mitigate functional limitations associated with knee osteoarthritis (OA). However, it is unclear whether walking on its own protects against the development of functional limitation.
Walking over 7 days was objectively measured as steps/day within a cohort of people with or at risk of knee OA from the Multicenter Osteoarthritis Study. Incident functional limitation over 2 years was defined by performance-based (gait speed <1.0 meter/second) and self-report (Western Ontario and McMaster Universities Osteoarthritis Index physical function score >28 of 68) measures. We evaluated the association of steps/day at baseline with developing functional limitation 2 years later by calculating risk ratios adjusted for potential confounders. The number of steps/day that best distinguished risk for developing functional limitation was estimated from the maximum distance from chance on receiver operating characteristic curves.
Among 1,788 participants (mean age 67 years, mean body mass index 31 kg/m(2) , 60% women), each additional 1,000 steps/day was associated with a 16% and 18% reduction in incident functional limitation by performance-based and self-report measures, respectively. Walking <6,000 and <5,900 steps/day were the best thresholds to distinguish incident functional limitation by performance-based (sensitivity 67.3%, specificity 71.8%) and self-report (sensitivity 58.7%, specificity 68.9%) measures, respectively.
More walking was associated with less risk of functional limitation over 2 years. Walking >6,000 steps/day provides a preliminary estimate of the level of walking activity to protect against developing functional limitation in people with or at risk of knee OA.
Details
- Title: Subtitle
- Daily walking and the risk of incident functional limitation in knee osteoarthritis: an observational study
- Creators
- Daniel K White - Boston University, Boston, MassachusettsCatrine Tudor-LockeYuqing ZhangRoger FieldingMichael LaValleyDavid T FelsonK Douglas Gross - Boston UniversityMichael C NevittCora E LewisJames TornerTuhina Neogi
- Resource Type
- Journal article
- Publication Details
- Arthritis care & research (2010), Vol.66(9), pp.1328-1336
- DOI
- 10.1002/acr.22362
- PMID
- 24923633
- PMCID
- PMC4146701
- NLM abbreviation
- Arthritis Care Res (Hoboken)
- ISSN
- 2151-464X
- eISSN
- 2151-4658
- Publisher
- United States
- Grant note
- U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS R24HD0065688 / NICHD NIH HHS AG-18947 / NIA NIH HHS 1P30AG031679 / NIA NIH HHS AR-47785 / NIAMS NIH HHS U01 AG019069 / NIA NIH HHS AG-19069 / NIA NIH HHS R24 HD065688 / NICHD NIH HHS P60 AR047785 / NIAMS NIH HHS AG-18820 / NIA NIH HHS R01AR062506 / NIAMS NIH HHS T32 AR007598 / NIAMS NIH HHS P30 AG031679 / NIA NIH HHS AR-007598 / NIAMS NIH HHS R01 AR062506 / NIAMS NIH HHS U01 AG018820 / NIA NIH HHS AG-18832 / NIA NIH HHS
- Language
- English
- Date published
- 09/2014
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983995180802771
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