Dam strain affects cardiovascular reactivity to acute stress in BHR

Carrol H Woodworth; Stein Knardahl; Brian J Sanders; Robert F Kirby; Alan Kim Johnson

doi:10.1016/0031-9384(90)90052-6

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Dam strain affects cardiovascular reactivity to acute stress in BHR

Journal article

Peer reviewed

Dam strain affects cardiovascular reactivity to acute stress in BHR

Carrol H Woodworth, Stein Knardahl, Brian J Sanders, Robert F Kirby and Alan Kim Johnson

Physiology & behavior, Vol.47(1), pp.139-144

1990

DOI: 10.1016/0031-9384(90)90052-6

PMID: 2326328

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Abstract

The effect of maternal strain on reactivity to acute stress was studied in F 1 reciprocals produced by crossing the spontaneously hypertensive rat (SHR) with its normotensive progenitor, the Wistar-Kyoto (WKY). This F 1 generation, known as the borderline hypertensive rat (BHR), is genetically predisposed to develop hypertension in response to chronic stress or high dietary sodium. Reciprocals, considered to be genetically equivalent aside from sex-linked traits, differ in strain of dam during intrauterine and preweanling development. At 17 weeks of age, reciprocal F 1 males did not differ in open-field behavior (squares crossed, rearings, and defecation measured over 3 days in 15-min sessions) or in home-cage measurements of mean arterial pressure (MAP) and heart rate (HR). However, different patterns of cardiovascular reactivity were displayed to transfer and footshock. While WKY-mothered rats reacted with graded pressor responses, SHR-mothered rats responded maximally to transfer, showed no additional increase to footshock, and maintained peak responding after footshock was terminated. Such reactivity differences may mediate the impact of environmental variables on the genetic disposition to hypertension.

Blood pressure

Borderline hypertensive rat

Footshock

Heart rate

Maternal effects

Open field

Stress

Details

Title: Subtitle: Dam strain affects cardiovascular reactivity to acute stress in BHR
Creators: Carrol H Woodworth
Stein Knardahl
Brian J Sanders
Robert F Kirby
Alan Kim Johnson
Resource Type: Journal article
Publication Details: Physiology & behavior, Vol.47(1), pp.139-144
DOI: 10.1016/0031-9384(90)90052-6
PMID: 2326328
NLM abbreviation: Physiol Behav
ISSN: 0031-9384
eISSN: 1873-507X
Publisher: Elsevier Inc
Language: English
Date published: 1990
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; University College Courses; Health, Sport, and Human Physiology
Record Identifier: 9984213428302771

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