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Damage to Ventromedial Prefrontal Cortex Impairs Judgment of Harmful Intent
Journal article   Open access   Peer reviewed

Damage to Ventromedial Prefrontal Cortex Impairs Judgment of Harmful Intent

Liane Young, Antoine Bechara, Daniel Tranel, Hanna Damasio, Marc Hauser and Antonio Damasio
Neuron (Cambridge, Mass.), Vol.65(6), pp.845-851
03/25/2010
DOI: 10.1016/j.neuron.2010.03.003
PMCID: PMC3085837
PMID: 20346759
url
https://doi.org/10.1016/j.neuron.2010.03.003View
Published (Version of record) Open Access

Abstract

Moral judgments, whether delivered in ordinary experience or in the courtroom, depend on our ability to infer intentions. We forgive unintentional or accidental harms and condemn failed attempts to harm. Prior work demonstrates that patients with damage to the ventromedial prefrontal cortex (VMPC) deliver abnormal judgments in response to moral dilemmas and that these patients are especially impaired in triggering emotional responses to inferred or abstract events (e.g., intentions), as opposed to real or actual outcomes. We therefore predicted that VMPC patients would deliver abnormal moral judgments of harmful intentions in the absence of harmful outcomes, as in failed attempts to harm. This prediction was confirmed in the current study: VMPC patients judged attempted harms, including attempted murder, as more morally permissible relative to controls. These results highlight the critical role of the VMPC in processing harmful intent for moral judgment. ► VMPC patients judged attempted harms as permissible, compared to control subjects ► VMPC patients judged attempted harms as more permissible than accidental harms ► VMPC is critical in processing harmful intentions for moral judgment ► Moral judgment may depend on emotional responses to harmful intent
humdisease sysneuro

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