Dapsone motor neuropathy--an axonal disease

Ludwig Gutmann; James D Martin; W Welton

doi:10.1212/WNL.26.6.514

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Dapsone motor neuropathy--an axonal disease

Journal article

Peer reviewed

Dapsone motor neuropathy--an axonal disease

Ludwig Gutmann, James D Martin and W Welton

Neurology, Vol.26(6 PT 1), pp.514-516

06/1976

DOI: 10.1212/WNL.26.6.514

PMID: 945490

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Abstract

Dapsone produces a potentially reversible toxic neuropathy, with its primary effect on the soma and axons of motor neurons as opposed to myelin. There is very little evidence to suggest involvement of sensory axons in most cases; if present, it would appear minimal. A "dying back" of motor axons is postulated to produce the clinical features of primarily distal weakness and wasting. Recovery appears to occur via axon regeneration and peripheral sprouting. The sporadic occurrence of this neuropathy may be due to slow acetylation of dapsone in some patients.

Action Potentials

Dapsone - adverse effects

Axons

Motor Neurons - physiology

Muscle Contraction

Neuromuscular Diseases - chemically induced

Humans

Middle Aged

Muscles - physiopathology

Male

Neural Conduction

Neuromuscular Diseases - physiopathology

Details

Title: Subtitle: Dapsone motor neuropathy--an axonal disease
Creators: Ludwig Gutmann
James D Martin
W Welton
Resource Type: Journal article
Publication Details: Neurology, Vol.26(6 PT 1), pp.514-516
Publisher: United States
DOI: 10.1212/WNL.26.6.514
PMID: 945490
ISSN: 0028-3878
eISSN: 1526-632X
Language: English
Date published: 06/1976
Academic Unit: Neurology
Record Identifier: 9984020757002771

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