Journal article
Data from a multi-year targeted proteomics study of a longitudinal birth cohort of type 1 diabetes
Scientific data, Vol.12(1), 112
01/20/2025
DOI: 10.1038/s41597-024-04249-1
PMCID: PMC11747092
PMID: 39833216
Abstract
The deployment of liquid chromatography-mass spectrometry-based plasma proteomics experiments in a large cohort is sparse, leading to a lack of data available for benchmarking, method development or validation. Comprised of 6,426 plasma analyses, The Environmental Determinants of Diabetes in the Young (TEDDY) proteomics validation study constitutes one of the largest targeted proteomics experiments in the literature to date. The proteomics data from this study were generated over the course of 2.5 years from over 900 study subjects, each providing up to 29 longitudinal samples. The data also includes 916 quality control samples. The targeted mass spectrometry assay was comprised of 694 peptides mapping to 167 proteins and the panel was measured in each subject and QC sample. The targeted proteomic dataset presented here can be used as a resource for new computational methods development, such as for batch correction, as well as for benchmarking and comparing the performance of different methods/tools.
Details
- Title: Subtitle
- Data from a multi-year targeted proteomics study of a longitudinal birth cohort of type 1 diabetes
- Creators
- Lisa M. Bramer - Pacific Northwest National LaboratoryErnesto S. Nakayasu - Pacific Northwest National LaboratoryJavier E. Flores - Pacific Northwest National LaboratoryJennifer E. Van Eyk - Cedars-Sinai Medical CenterMichael J. Maccoss - University of WashingtonHemang M. Parikh - University of South FloridaThomas O. Metz - Pacific Northwest National LaboratoryBobbie-Jo M. Webb-Robertson - Pacific Northwest National Laboratory
- Resource Type
- Journal article
- Publication Details
- Scientific data, Vol.12(1), 112
- DOI
- 10.1038/s41597-024-04249-1
- PMID
- 39833216
- PMCID
- PMC11747092
- NLM abbreviation
- Sci Data
- ISSN
- 2052-4463
- eISSN
- 2052-4463
- Publisher
- NATURE PORTFOLIO
- Number of pages
- 8
- Grant note
- HHSN267200700014C; DEAC05-76RLO1830; U01 DK63829; U01 DK63861; U01 DK63821; U01 DK63865; U01 DK63863; U01 DK63836; U01 DK63790; UC4 DK63829; UC4 DK63861; UC4 DK63821; UC4 DK63865; UC4 DK63863; UC4 DK63836; UC4 DK95300; UC4 DK100238; UC4 DK106955; UC4 DK112243; UC4 DK117483; U01 DK124166; U01 DK128847 / U.S. Department of Energy (DOE); United States Department of Energy (DOE) PNNL UL1 TR002535 / NIH/NCATS Clinical and Translational Science Awards to the University of Florida HHSN267200700014C; U01 DK127786 / National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) National Institute of Allergy and Infectious Diseases (NIAID); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) U01 KD127786-S1 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) University of Colorado National Institute of Environmental Health Sciences (NIEHS); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Language
- English
- Date published
- 01/20/2025
- Academic Unit
- Biostatistics
- Record Identifier
- 9985112969602771
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