Data on the relationship of signal-to-cutoff ratio of two HIV antigen/antibody combination assays to subsequent confirmation of HIV-1 infection in a low-prevalence population

Christina K Hodgson; Matthew D Krasowski; Bradley A Ford

doi:10.1016/j.dib.2020.105707

Back

Data on the relationship of signal-to-cutoff ratio of two HIV antigen/antibody combination assays to subsequent confirmation of HIV-1 infection in a low-prevalence population

Journal article

Open access

Peer reviewed

Data on the relationship of signal-to-cutoff ratio of two HIV antigen/antibody combination assays to subsequent confirmation of HIV-1 infection in a low-prevalence population

Christina K Hodgson, Matthew D Krasowski and Bradley A Ford

Data in brief, Vol.31, pp.105707-105707

08/2020

DOI: 10.1016/j.dib.2020.105707

PMID: 32462068

Files and links (1)

url

https://doi.org/10.1016/j.dib.2020.105707View

Published (Version of record) Open Access

Abstract

HIV-1/2 antigen/antibody (Ag/Ab) immunoassays that detect HIV-1 and HIV-2 antibodies and HIV-1 p24 antigen are commonly used in the diagnosis of HIV-1/HIV-2 infections in human plasma/serum. Samples from patients with positive screening results require confirmation by antibody differentiation and/or HIV PCR assays. HIV screening assays are commonly reported as positive or negative based on a signal-to-cutoff (S/CO) threshold. For some HIV screening assays, the strength of the S/CO value correlates with likelihood that confirmatory testing will be positive. The data in this article provide results from two HIV Ag/Ab combination assays (Abbott Architect HIV Ag/Ab Combo Assay, a 4 generation combination assay; Bio-Rad Bioplex 2200 HIV Ag-Ab Assay, a 5 generation assay). The data include 23,331 HIV screening results, S/CO ratios, antibody differentiation or Western blot results (for samples with positive HIV screens), HIV-1 PCR results (if performed), patient location at time of testing, age, and sex. Distribution of S/CO ratios for the Bio-Rad HIV screening assay data and the distribution of S/CO values for samples with positive screening results were analyzed.

HIV-1

HIV-2

viral load

polymerase chain reaction

False positive reaction

immunoassay

Details

Title: Subtitle: Data on the relationship of signal-to-cutoff ratio of two HIV antigen/antibody combination assays to subsequent confirmation of HIV-1 infection in a low-prevalence population
Creators: Christina K Hodgson - University of Iowa Hospitals and Clinics
Matthew D Krasowski - University of Iowa Hospitals and Clinics
Bradley A Ford - University of Iowa Hospitals and Clinics
Resource Type: Journal article
Publication Details: Data in brief, Vol.31, pp.105707-105707
DOI: 10.1016/j.dib.2020.105707
PMID: 32462068
NLM abbreviation: Data Brief
ISSN: 2352-3409
eISSN: 2352-3409
Language: English
Date published: 08/2020
Academic Unit: Pathology
Record Identifier: 9984186440002771

Metrics

30 Record Views

5 Times Cited - Web of Science