Dataset describing maternal prenatal restraint stress effects on immune factors in mice

Serena Banu Gumusoglu; Sara Victoria Maurer; Hanna Elizabeth Stevens

doi:10.1016/j.dib.2022.108348

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Dataset describing maternal prenatal restraint stress effects on immune factors in mice

Journal article

Open access

Peer reviewed

Dataset describing maternal prenatal restraint stress effects on immune factors in mice

Serena Banu Gumusoglu, Sara Victoria Maurer and Hanna Elizabeth Stevens

Data in brief, Vol.43, pp.108348-108348

08/2022

DOI: 10.1016/j.dib.2022.108348

PMCID: PMC9189994

PMID: 35707242

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https://doi.org/10.1016/j.dib.2022.108348View

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Abstract

Maternal immune dysregulation, caused by gestational psychological stress, infection, and other perturbations, results in altered offspring neurodevelopment and increases risk for psychiatric disorders. Prior work has found that multiple cytokines play critical roles in shaping offspring neurodevelopment after gestational stress, though how maternal psychological stress impacts maternal, placental, and fetal cytokine levels more broadly remains unclear. The purpose of the present study was to assess changes to IL-1β, IL-2, IL-4, IL-6, IL-10, IL-17A, IFNγ, and TNFα in a widely-used mouse prenatal restraint stress model. After repetitive restraint stress on gestational days 12–14, stressed dams had increased serum levels of IL-1β, IL-6, and IL-10. Embryonic day 14 IL-2 and IL-1β levels were decreased in prenatally stressed male fetal forebrain, while placental IL-2 was decreased by stress regardless of offspring sex. Placental and fetal forebrain IL-2 levels were negatively correlated. These data provide important insights into the immune changes that occur with prenatal restraint stress.

Animal Models

Cytokines

Inflammation

Chemokines

Prenatal stress

Restraint stress

Details

Title: Subtitle: Dataset describing maternal prenatal restraint stress effects on immune factors in mice
Creators: Serena Banu Gumusoglu - Interdisciplinary Graduate Program in Neuroscience, University of Iowa, 200 Hawkins Dr., Iowa City, IA 52242 USA
Sara Victoria Maurer - University of Iowa
Hanna Elizabeth Stevens - Interdisciplinary Graduate Program in Neuroscience, University of Iowa, 200 Hawkins Dr., Iowa City, IA 52242 USA
Resource Type: Journal article
Publication Details: Data in brief, Vol.43, pp.108348-108348
DOI: 10.1016/j.dib.2022.108348
PMID: 35707242
PMCID: PMC9189994
NLM abbreviation: Data Brief
ISSN: 2352-3409
eISSN: 2352-3409
Publisher: Elsevier Inc
Language: English
Date published: 08/2022
Academic Unit: Psychiatry; Iowa Neuroscience Institute; Obstetrics and Gynecology
Record Identifier: 9984267241602771

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