Journal article
De-Novo Hepatic Angiosarcoma in a Liver Transplant Recipient
Transplantation proceedings, Vol.57(7), pp.1348-1351
09/2025
DOI: 10.1016/j.transproceed.2025.03.031
PMID: 40287304
Abstract
•Organ transplant patients have an increased risk of malignant neoplasms.•De-novo hepatic angiosarcoma in liver transplant recipients has not been described.•Medical management of hepatic angiosarcoma is quite limited.•Prognosis is incredibly poor, with average life expectancy 5 to 6 months.
Angiosarcoma (AS) is a rare and highly aggressive soft tissue tumor. Cases of de-novo hepatic angiosarcoma after liver transplantation have not been described in the literature. Here, we present an exceedingly rare case of hepatic AS developing in a patient with a liver transplant (LT). A 72-year-old male with a history of orthotopic LT presented with cholestatic pattern of liver enzyme elevation for 3 months. Six years prior, he had undergone LT for treatment of alcohol-associated cirrhosis. He was on everolimus (1 mg twice daily) and low-dose tacrolimus (0.5 mg twice daily) for immunosuppression without evidence of allograft rejection. At presentation, his ALP and GGT were elevated to 1-2 times the upper limit of normal. He endorsed a 20-pound weight loss, anorexia, abdominal pain, and distention. A right upper quadrant ultrasound with doppler revealed a 14 cm liver mass and moderate ascites. This was followed by a multiphasic abdominal MRI, which revealed a 14.9 cm central hepatic mass involving the right and left hepatic lobes with extension into the hepatic veins and the inferior vena cava. The patient underwent a core biopsy of the tumor, which was suggestive of high-grade liver AS. A follow-up PET/CT scan was concerning for right adrenal gland and bilateral pulmonary metastasis. Patient was discussed at multidisciplinary tumor board and started on palliative chemotherapy with a single agent (docetaxel). Due to medication intolerance, patient discontinued the regimen after 1 cycle, and opted to transition to comfort care. He passed away 3 months after initial diagnosis.
Details
- Title: Subtitle
- De-Novo Hepatic Angiosarcoma in a Liver Transplant Recipient
- Creators
- Alp Serhat Kahveci - University of IowaAysha Aslam - Division of Gastroenterology and Hepatology, University of Iowa Hospitals and Clinics, Iowa City, USAYiqin Xiong - University of IowaTomohiro Tanaka - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Transplantation proceedings, Vol.57(7), pp.1348-1351
- DOI
- 10.1016/j.transproceed.2025.03.031
- PMID
- 40287304
- NLM abbreviation
- Transplant Proc
- ISSN
- 0041-1345
- eISSN
- 1873-2623
- Publisher
- Elsevier Inc
- Language
- English
- Electronic publication date
- 04/26/2025
- Date published
- 09/2025
- Academic Unit
- Health Management and Policy; Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984815909002771
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