Death begets failure in the heart

Roger S-Y Foo; Kartik Mani; Richard N Kitsis

doi:10.1172/JCI24569

Back

Journal article

Open access

Peer reviewed

Death begets failure in the heart

Roger S-Y Foo, Kartik Mani and Richard N Kitsis

The Journal of clinical investigation, Vol.115(3), pp.565-571

03/2005

DOI: 10.1172/JCI24569

PMCID: PMC1052022

PMID: 15765138

Files and links (1)

url

https://doi.org/10.1172/JCI24569View

Published (Version of record) Open Access

Abstract

Recently, low--but abnormal--rates of cardiomyocyte apoptosis have been observed in failing human hearts. Genetic and pharmacological studies suggest that this cell death is causally linked to heart failure in rodent models. Herein, we review these data and discuss potential therapeutic implications.

Animals

Apoptosis - physiology

Cardiac Output, Low - metabolism

Cardiac Output, Low - pathology

Cardiac Output, Low - therapy

Humans

Myocytes, Cardiac - cytology

Myocytes, Cardiac - metabolism

Signal Transduction - physiology

Details

Title: Subtitle: Death begets failure in the heart
Creators: Roger S-Y Foo - Albert Einstein College of Medicine
Kartik Mani
Richard N Kitsis
Resource Type: Journal article
Publication Details: The Journal of clinical investigation, Vol.115(3), pp.565-571
DOI: 10.1172/JCI24569
PMID: 15765138
PMCID: PMC1052022
NLM abbreviation: J Clin Invest
ISSN: 0021-9738
eISSN: 1558-8238
Publisher: AMER SOC CLINICAL INVESTIGATION INC; ANN ARBOR
Grant note: R01 HL073732 / NHLBI NIH HHS R01 HL61550 / NHLBI NIH HHS R01 HL60665 / NHLBI NIH HHS R01 HL061550 / NHLBI NIH HHS R01 HL060665 / NHLBI NIH HHS R01 HL73732 / NHLBI NIH HHS
Language: English
Date published: 03/2005
Academic Unit: Internal Medicine
Record Identifier: 9984695834502771

Metrics

4 Record Views

247 Times Cited - Web of Science