Journal article
Death in hospital following ICU discharge: insights from the LUNG SAFE study
Critical care (London, England), Vol.25(1), pp.144-144
04/13/2021
DOI: 10.1186/s13054-021-03465-0
PMCID: PMC8043098
PMID: 33849625
Abstract
Background To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward. Methods The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from 50 countries globally. This study aimed to understand the frequency and factors associated with death in hospital in patients who survived their ICU stay. We examined outcomes in the subpopulation discharged with no limitations of life sustaining treatments ('treatment limitations'), and the subpopulations with treatment limitations. Results 2186 (94%) patients with no treatment limitations discharged from ICU survived, while 142 (6%) died in hospital. 118 (61%) of patients with treatment limitations survived while 77 (39%) patients died in hospital. Patients without treatment limitations that died in hospital after ICU discharge were older, more likely to have COPD, immunocompromise or chronic renal failure, less likely to have trauma as a risk factor for ARDS. Patients that died post ICU discharge were less likely to receive neuromuscular blockade, or to receive any adjunctive measure, and had a higher pre- ICU discharge non-pulmonary SOFA score. A similar pattern was seen in patients with treatment limitations that died in hospital following ICU discharge. Conclusions A significant proportion of patients die in hospital following discharge from ICU, with higher mortality in patients with limitations of life-sustaining treatments in place. Non-survivors had higher systemic illness severity scores at ICU discharge than survivors. Trial Registration: ClinicalTrials.gov .
Details
- Title: Subtitle
- Death in hospital following ICU discharge: insights from the LUNG SAFE study
- Creators
- Fabiana Madotto - MultiMedicaBairbre McNicholas - Ollscoil na Gaillimhe – University of GalwayEmanuele Rezoagli - University of Milano-BicoccaTai Pham - Bicêtre HospitalJohn G. Laffey - Ollscoil na Gaillimhe – University of GalwayGiacomo Bellani - University of Milano-BicoccaESICM Trials GroupLUNG SAFE Investigators
- Contributors
- Nicholas M Mohr (Contributor) - University of Iowa, Anesthesia
- Resource Type
- Journal article
- Publication Details
- Critical care (London, England), Vol.25(1), pp.144-144
- DOI
- 10.1186/s13054-021-03465-0
- PMID
- 33849625
- PMCID
- PMC8043098
- NLM abbreviation
- Crit Care
- ISSN
- 1364-8535
- eISSN
- 1466-609X
- Publisher
- Springer Nature
- Number of pages
- 17
- Grant note
- St Michael's Hospital, Toronto, Canada 16-FRL-3845 / Science Foundation Ireland Future Research Leaders Award; Science Foundation Ireland European Society of Intensive Care Medicine (ESICM), Brussels, Belgium Italian Ministry of University and Research (MIUR)-Department of Excellence project PREMIA (PREcision MedIcine Approach: bringing biomarker research to clinic); Ministry of Education, Universities and Research (MIUR) University of Milan-Bicocca, Monza, Italy
- Language
- English
- Date published
- 04/13/2021
- Academic Unit
- Epidemiology; Emergency Medicine; Anesthesia; Injury Prevention Research Center
- Record Identifier
- 9984296152502771
Metrics
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