Debulking surgery prior to stereotactic radiotherapy for head and neck paragangliomas

Geovanne Pedro Mauro; Leila Maria Da Roz; Vinicius de Carvalho Gico; Eduardo Weltman; Evandro Cesar De Souza; Helena Espindola Baraldi; Eberval Gadelha Figueiredo; Carlos Gilberto Carlotti

doi:10.5603/rpor.101802

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Debulking surgery prior to stereotactic radiotherapy for head and neck paragangliomas

Journal article

Peer reviewed

Debulking surgery prior to stereotactic radiotherapy for head and neck paragangliomas

Geovanne Pedro Mauro, Leila Maria Da Roz, Vinicius de Carvalho Gico, Eduardo Weltman, Evandro Cesar De Souza, Helena Espindola Baraldi, Eberval Gadelha Figueiredo and Carlos Gilberto Carlotti

Reports of practical oncology and radiotherapy, Vol.29(4), pp.454-459

01/01/2024

DOI: 10.5603/rpor.101802

PMCID: PMC11785380

PMID: 39895960

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Abstract

Background: Surgery has been used as standard treatment for head and neck paragangliomas. Stereotactic radiotherapy (SRT) has also been increasingly used for this disease. The results for combined modality are not well described. This analysis aims to describe the results for combined modality of debulking surgery and SRT for head and neck paragangliomas (HNP). Materials and and methods: Retrospective cohort of patients treated in a large university hospital between 2008 and 2023. Results: Fifty-one patients had their charts reviewed. Mean age was 56.3 years. Most were female (82.3%). Most lesions arose from the skull-base (84.3%) and not the inner ear. Most lesions were larger than 3 cm (51.0%) and mean lesion size was 4.4 cm. 36 (70.6%) were treated with radiotherapy alone while 15 (29.4%) were treated with combined modality treatment. Median follow-up was 42.5 months (7.1-112.8 months). There were no reported deaths nor disease progression. Debulking surgery did not impact response rate for SRT (52.8% vs. 47.2% for SRT alone and debulking surgery, respectively, p = 0.971). There was no impact on new neurological deficits after SRT (25.0 vs. 13.3%, respectively, p = 0.356). Conclusion: Debulking surgery did not improve response rate for SRT. In our sample, it also did not impact new neurological deficits for SRT. Prospective data regarding HNP treatment is needed.

Oncology

Life Sciences & Biomedicine

Radiology, Nuclear Medicine & Medical Imaging

Science & Technology

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Title: Subtitle: Debulking surgery prior to stereotactic radiotherapy for head and neck paragangliomas
Creators: Geovanne Pedro Mauro - Universidade de São Paulo
Leila Maria Da Roz - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Vinicius de Carvalho Gico - Universidade de São Paulo
Eduardo Weltman - Universidade de São Paulo
Evandro Cesar De Souza - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Helena Espindola Baraldi - Universidade de São Paulo
Eberval Gadelha Figueiredo - Universidade de São Paulo
Carlos Gilberto Carlotti - Universidade de São Paulo
Resource Type: Journal article
Publication Details: Reports of practical oncology and radiotherapy, Vol.29(4), pp.454-459
DOI: 10.5603/rpor.101802
PMID: 39895960
PMCID: PMC11785380
NLM abbreviation: Rep Pract Oncol Radiother
ISSN: 1507-1367
eISSN: 2083-4640
Publisher: Via Medica
Number of pages: 6
Language: English
Date published: 01/01/2024
Academic Unit: Radiation Oncology
Record Identifier: 9984914017502771

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