Decelerated early growth in infants of overweight and obese mothers

Katie  Larson Ode; Heather L Gray; Sara E Ramel; Michael K Georgieff; Ellen W Demerath

doi:10.1016/j.jpeds.2012.06.001

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Decelerated early growth in infants of overweight and obese mothers

Journal article

Peer reviewed

Decelerated early growth in infants of overweight and obese mothers

Katie Larson Ode, Heather L Gray, Sara E Ramel, Michael K Georgieff and Ellen W Demerath

The Journal of pediatrics, Vol.161(6), pp.1028-1034

12/2012

DOI: 10.1016/j.jpeds.2012.06.001

PMCID: PMC3480982

PMID: 22819273

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Abstract

To investigate the relationship between maternal prepregnancy body mass index and early infant growth and body composition. Prospective cohort study performed at a university hospital/surrounding community. Ninety-seven nondiabetic mothers with singleton, term, healthy infants completed study visits at 2 weeks and 3 months of age. Before pregnancy, 59 mothers were normal weight, 18 were overweight, and 20 were obese. Infant anthropometrics and body composition via air-displacement plethysmography were measured. Infant feeding information and maternal prepregnancy weight were self-reported. Additional data were obtained via self-report and the medical record. Main outcome measures were change in weight, length, fat-free mass, and fat mass from 2 weeks to 3 months of age. Analysis was done via multivariate linear regression. At 2 weeks, anthropometrics and body composition did not differ across maternal body mass index groups. At 3 months, infants of overweight or obese mothers had gained less weight (P = .02), grew less in length (P = .01), and gained less fat mass (P = .01). Adjustment for breastfeeding status and regression to the mean via conditional change variables did not alter the results. The results were not altered after adjusting for maternal glucose values from a 50-g glucose challenge and for maternal smoking in a subset including 80% of the women. Maternal overweight/obesity is associated with early deceleration in linear growth and adipose tissue accrual; replication of these findings is needed.

Breast Feeding

Child Development

Obesity

Pregnancy

Body Mass Index

Multivariate Analysis

Prospective Studies

Humans

Pregnancy Complications

Self Report

Infant

Linear Models

Male

Overweight

Adiposity

Adult

Body Height

Female

Weight Gain

Plethysmography

Cohort Studies

Details

Title: Subtitle: Decelerated early growth in infants of overweight and obese mothers
Creators: Katie Larson Ode - Department of Pediatrics, University of Iowa, Iowa City, IA, USA. katie-larsonode@uiowa.edu
Heather L Gray - University of Minnesota
Sara E Ramel - University of Minnesota
Michael K Georgieff - University of Minnesota
Ellen W Demerath - University of Minnesota
Resource Type: Journal article
Publication Details: The Journal of pediatrics, Vol.161(6), pp.1028-1034
DOI: 10.1016/j.jpeds.2012.06.001
PMID: 22819273
PMCID: PMC3480982
NLM abbreviation: J Pediatr
ISSN: 0022-3476
eISSN: 1097-6833
Grant note: T32 DK065519 / NIDDK NIH HHS U54 CA116849 / NCI NIH HHS
Language: English
Date published: 12/2012
Academic Unit: Endocrinology and Diabetes; Stead Family Department of Pediatrics
Record Identifier: 9984093496802771

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