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Deciphering Hepatic Dilemmas: A Case of Acute Hepatitis Following Malaria Treatment
Journal article   Open access   Peer reviewed

Deciphering Hepatic Dilemmas: A Case of Acute Hepatitis Following Malaria Treatment

Sydney Lovrien, Erin Quist, Dayana Maita Coronel, Ashwani K. Singal and Chencheng Xie
Case reports in gastrointestinal medicine, Vol.2025(1), 9995249
12/28/2025
DOI: 10.1155/crgm/9995249
PMID: 41466773
url
https://doi.org/10.1155/crgm/9995249View
Published (Version of record) Open Access

Abstract

Malaria can be a life-threatening disease, but it rarely presents with acute hepatitis. This case reports the medical course of a 55-year-old African woman afflicted with P. falciparum malaria, recently treated in Cameroon, who presented with jaundice and transaminitis. Her liver biopsy indicated cholestatic hepatitis. Her diagnosis was complicated by the fact that only one of four follow-up thick and thin blood smears was positive for P. falciparum. After more than 17 months of follow-up, her liver enzymes and bilirubin returned to baseline without further malaria treatment, and her findings were attributed to drug-induced liver injury caused by antimalarial medications.
Hepatitis Malaria UIOWA OA Agreement drug-induced liver injury

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