Journal article
Deciphering regulatory protein activity in human pancreatic islets via reverse engineering of single-cell sequencing data
The Journal of clinical investigation, Vol.131(24), e154482
12/15/2021
DOI: 10.1172/JCI154482
PMCID: PMC8670832
PMID: 34907912
Abstract
The loss of functional beta cell mass contributes to development and progression of type 2 diabetes (T2D). However, the molecular mechanisms differentiating islet dysfunction in T2D from nondiabetic states remain elusive. In this issue of the JCI, Son et al. applied reverse engineering to obtain the activity of gene expression regulatory proteins from single-cell RNA sequencing data of nondiabetic and T2D human islets. The authors identify unique patterns of regulatory protein activities associated with T2D. Furthermore, BACH2 emerged as a potential transcription factor that drives activation of T2D-associated regulatory proteins in human islets.
Details
- Title: Subtitle
- Deciphering regulatory protein activity in human pancreatic islets via reverse engineering of single-cell sequencing data
- Creators
- Yumi Imai - University of Iowa, Internal Medicine
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.131(24), e154482
- Publisher
- Amer Soc Clinical Investigation Inc
- DOI
- 10.1172/JCI154482
- PMID
- 34907912
- PMCID
- PMC8670832
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Number of pages
- 4
- Grant note
- I01 BX005107 / Department of Veteran Affairs; US Department of Veterans Affairs R01-DK090490 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Fraternal Orders of Eagles Diabetes Research Cen-ter at the University of Iowa
- Language
- English
- Date published
- 12/15/2021
- Academic Unit
- Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984359899302771
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