Decoding arenavirus pathogenesis: Essential roles for alpha-dystroglycan-virus interactions and the immune response

Michael B.A Oldstone; Kevin P Campbell

doi:10.1016/j.virol.2010.11.023

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Decoding arenavirus pathogenesis: Essential roles for alpha-dystroglycan-virus interactions and the immune response

Journal article

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Peer reviewed

Decoding arenavirus pathogenesis: Essential roles for alpha-dystroglycan-virus interactions and the immune response

Michael B.A Oldstone and Kevin P Campbell

Virology (New York, N.Y.), Vol.411(2), pp.170-179

03/15/2011

DOI: 10.1016/j.virol.2010.11.023

PMCID: PMC3071849

PMID: 21185048

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Abstract

Pathogenesis following a virus infection results from interactions between the virus and its host. The outcome is determined by tipping the balance between virulence of the virus or susceptibility/resistance of the host to favor one or the other. This review focuses on two important members of the Old World arenavirus family: Lassa fever virus (LFV), a robust human pathogen that causes a severe acute hemorrhagic disease; and lymphocytic choriomeningitis virus (LCMV), also a human pathogen but better known in the context of its rodent model. Research with this model has uncovered and illuminated many of our current concepts in immunobiology and viral pathogenesis. Presented here are recent advances that form the framework for a better understanding of how viruses induce and maintain persistent infection as well as for the pathogenesis associated with acute LFV infection. A major component for understanding the pathogenesis of these arenaviruses revolves around study of the interaction of virus with its receptor, alpha-dystroglycan (α-DG).

Lymphocytic choriomeningitis virus

alpha-dystroglycan

LARGE

Lassa fever virus

Molecular pathogenesis

Details

Title: Subtitle: Decoding arenavirus pathogenesis: Essential roles for alpha-dystroglycan-virus interactions and the immune response
Creators: Michael B.A Oldstone - Viral-Immunobiology Laboratory, Department of Immunology & Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Kevin P Campbell - Howard Hughes Medical Institute, Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, 4283 Carver Biomedical Research Building, 285 Newton Road, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Virology (New York, N.Y.), Vol.411(2), pp.170-179
DOI: 10.1016/j.virol.2010.11.023
PMID: 21185048
PMCID: PMC3071849
NLM abbreviation: Virology
ISSN: 0042-6822
eISSN: 1096-0341
Publisher: Elsevier Inc
Grant note: name: NIH, award: AI009484, AI045927
Language: English
Date published: 03/15/2011
Academic Unit: Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
Record Identifier: 9984068277502771

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