Journal article
Deconstructing the mechanisms and consequences of TGF-beta-induced EMT during cancer progression
Cell and tissue research, Vol.347(1), pp.85-101
01/01/2012
DOI: 10.1007/s00441-011-1199-1
PMCID: PMC3723118
PMID: 21691718
Abstract
Transforming growth factor-beta (TGF-beta) is a potent pleiotropic cytokine that regulates mammalian development, differentiation, and homeostasis in essentially all cell types and tissues. TGF-beta normally exerts anticancer activities by prohibiting cell proliferation and by creating cell microenvironments that inhibit cell motility, invasion, and metastasis. However, accumulating evidence indicates that the process of tumorigenesis, particularly that associated with metastatic progression, confers TGF-beta with oncogenic activities, a functional switch known as the "TGF-beta paradox." The molecular determinants governing the TGF-beta paradox are complex and represent an intense area of investigation by researchers in academic and industrial settings. Recent findings link genetic and epigenetic events in mediating the acquisition of oncogenic activity by TGF-beta, as do aberrant alterations within tumor microenvironments. These events coalesce to enable TGF-beta to direct metastatic progression via the stimulation of epithelial-mesenchymal transition (EMT), which permits carcinoma cells to abandon polarized epithelial phenotypes in favor of apolar mesenchymal-like phenotypes. Attempts to deconstruct the EMT process induced by TGF-beta have identified numerous signaling molecules, transcription factors, and microRNAs operant in mediating the initiation and resolution of this complex transdifferentiation event. In addition to its ability to enhance carcinoma cell invasion and metastasis, EMT also endows transitioned cells with stem-like properties, including the acquisition of self-renewal and tumor-initiating capabilities coupled to chemoresistance. Here, we review recent findings that delineate the pathophysiological mechanisms whereby EMT stimulated by TGF-beta promotes metastatic progression and disease recurrence in human carcinomas.
Details
- Title: Subtitle
- Deconstructing the mechanisms and consequences of TGF-beta-induced EMT during cancer progression
- Creators
- Michael K. Wendt - Case Western Reserve UniversityMaozhen Tian - Case Western Reserve UniversityWilliam P. Schiemann - Case Western Reserve University
- Resource Type
- Journal article
- Publication Details
- Cell and tissue research, Vol.347(1), pp.85-101
- Publisher
- Springer Nature
- DOI
- 10.1007/s00441-011-1199-1
- PMID
- 21691718
- PMCID
- PMC3723118
- ISSN
- 0302-766X
- eISSN
- 1432-0878
- Number of pages
- 17
- Grant note
- BC084651 / Department of Defense; United States Department of Defense R01CA129359 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Case Comprehensive Cancer Center University Hospitals Seidman Cancer Center CA129359 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA PF-09-120-01-CS / American Cancer Society BCTR0706967 / Komen Foundation; Susan G. Komen Breast Cancer Foundation
- Language
- English
- Date published
- 01/01/2012
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984460335702771
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