Journal article
Decreased Cerebral ATP in Pre-Motor Manifest Huntington’s Disease: A Pilot Study
Parkinsonism & related disorders, Vol.140, 108040
11/2025
DOI: 10.1016/j.parkreldis.2025.108040
PMID: 40974859
Abstract
Background
Huntington's Disease (HD) is characterized by brain metabolic dysfunction, but no studies to date have directly measured cerebral ATP levels in patients with HD.
Objective
To compare cerebral ATP between individuals with pre-motor-manifest HD (preHD) and healthy controls (HC).
Methods
Cerebral ATP was quantified using 31Phosphorous Magnetic Resonance Spectroscopy (31P-MRS) at 7T in nine preHD subjects and nine HC subjects. Analysis of Covariance models were constructed to compare mean ATP signal (corrected by whole brain volume) between groups after adjusting for age and BMI.
Results
PreHD participants exhibited significantly lower total ATP compared to HCs; furthermore, preHD subjects with higher clinical burden of disease had lower ATP levels. Amongst the preHD subjects, lower ATP levels were associated with worsening composite Unified Huntington's Disease Rating Scale scores.
Conclusions
Our findings highlight the potential of 31P-MRS to serve as a direct assay for metabolic dysfunction in HD.
Details
- Title: Subtitle
- Decreased Cerebral ATP in Pre-Motor Manifest Huntington’s Disease: A Pilot Study
- Creators
- Lindsay E. Golden - University of IowaJia Xu - University of Iowa, RadiologyVincent A. Magnotta - University of IowaPeg C. Nopoulos - University of IowaJordan L. Schultz - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Parkinsonism & related disorders, Vol.140, 108040
- DOI
- 10.1016/j.parkreldis.2025.108040
- PMID
- 40974859
- NLM abbreviation
- Parkinsonism Relat Disord
- ISSN
- 1353-8020
- eISSN
- 1873-5126
- Publisher
- Elsevier
- Grant note
- National Institute of Neurological Disorders and Stroke: K23-NS117736 Iowa Neuroscience InstituteNIHNINDS: U01-NS055903
This work was funded by the National Institute of Neurological Disorders and Stroke (K23-NS117736 to JLS) and the Iowa Neuroscience Institute. JLS serves as a consultant for the Huntington's Study Group. Support provided to VAM from P50-HD103556. Images collected in this study were collected on a scanner funded by NIH Grant S10-OD025025. PCN receives salary and research support from NINDS (U01-NS055903) . PCN serves as a consultant on a Scientific Advisory Board for Novartis. All other authors declare no competing interests or financial disclosures for the preceding 12 months.
- Language
- English
- Electronic publication date
- 09/15/2025
- Date published
- 11/2025
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984964238302771
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