Decreased E-cadherin but not beta-catenin expression is associated with vascular invasion and decreased survival in head and neck squamous carcinomas

Kevin A Kurtz; Henry T Hoffman; M Bridget Zimmerman; Robert A Robinson

doi:10.1016/j.otohns.2005.08.026

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Decreased E-cadherin but not beta-catenin expression is associated with vascular invasion and decreased survival in head and neck squamous carcinomas

Journal article

Peer reviewed

Decreased E-cadherin but not beta-catenin expression is associated with vascular invasion and decreased survival in head and neck squamous carcinomas

Kevin A Kurtz, Henry T Hoffman, M Bridget Zimmerman and Robert A Robinson

Otolaryngology--head and neck surgery, Vol.134(1), pp.142-146

01/2006

DOI: 10.1016/j.otohns.2005.08.026

PMID: 16399195

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Abstract

We wished to correlate the expression of E-cadherin and beta-catenin in squamous carcinomas of the head and neck to outcome and other clinicopathologic variables. This retrospective study was carried out in a tertiary care setting. The tumors of 45 patients who had their head and neck squamous carcinoma primarily treated by resection were evaluated immunohistochemically with antibodies to E-cadherin and beta-catenin. Thirty-two tumors arose in the oral cavity, 9 tumors originated in the larynx, and 4 tumors began in the hypopharynx. Patient outcome and the clinicopathologic variables of tumor site, tumor stage, cervical lymph node status, tumor differentiation, perineural invasion, and vascular invasion were correlated to immunohistochemical expression of E-cadherin and beta-catenin. Low expression of E-cadherin in the tumors was significantly associated with decreased overall survival (P = 0.004), disease-free survival (P = 0.007), and vascular invasion (P = 0.02) but not with other clinicopathologic variables. beta-catenin expression was not significantly associated with any of the studied clinicopathologic variables. Decreased E-cadherin but not beta-catenin expression is associated with decreased survival in patients with head and neck squamous carcinomas. Detection of loss of E-cadherin expression may help predict which patients with head and neck squamous cell carcinoma will experience a worse outcome compared to patients whose tumors have not lost this tumor suppressor. C-4.

Cadherins - metabolism

Neoplasm Invasiveness

Carcinoma, Squamous Cell - metabolism

Carcinoma, Squamous Cell - pathology

Humans

Middle Aged

Male

Survival Rate

beta Catenin - metabolism

Head and Neck Neoplasms - metabolism

Head and Neck Neoplasms - pathology

Carcinoma, Squamous Cell - mortality

Aged, 80 and over

Adult

Endothelium, Vascular - pathology

Female

Aged

Retrospective Studies

Head and Neck Neoplasms - mortality

Details

Title: Subtitle: Decreased E-cadherin but not beta-catenin expression is associated with vascular invasion and decreased survival in head and neck squamous carcinomas
Creators: Kevin A Kurtz - Department of Pathology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
Henry T Hoffman
M Bridget Zimmerman
Robert A Robinson
Resource Type: Journal article
Publication Details: Otolaryngology--head and neck surgery, Vol.134(1), pp.142-146
Publisher: England
DOI: 10.1016/j.otohns.2005.08.026
PMID: 16399195
ISSN: 0194-5998
eISSN: 1097-6817
Language: English
Date published: 01/2006
Academic Unit: Oral Pathology, Radiology and Medicine; Pathology; Biostatistics; Radiation Oncology; Otolaryngology
Record Identifier: 9983997470502771

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