Journal article
Decreased availability of nitric oxide and hydrogen sulfide is a hallmark of COVID-19
Redox biology, Vol.43, pp.101982-101982
07/2021
DOI: 10.1016/j.redox.2021.101982
PMCID: PMC8106525
PMID: 34020311
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is involved in a global outbreak affecting millions of people who manifest a variety of symptoms. Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is increasingly associated with cardiovascular complications requiring hospitalizations; however, the mechanisms underlying these complications remain unknown. Nitric oxide (NO) and hydrogen sulfide (H2S) are gasotransmitters that regulate key cardiovascular functions.
Blood samples were obtained from 68 COVID-19 patients and 33 controls and NO and H2S metabolites were assessed. H2S and NO levels were compared between cases and controls in the entire study population and subgroups based on race. The availability of gasotransmitters was examined based on severity and outcome of COVID-19 infection. The performance of H2S and NO levels in predicting COVID-19 infection was also analyzed. Multivariable regression analysis was performed to identify the effects of traditional determinants of gasotransmitters on NO and H2S levels in the patients with COVID-19 infection.
Significantly reduced NO and H2S levels were observed in both Caucasian and African American COVID-19 patients compared to healthy controls. COVID-19 patients who died had significantly higher NO and H2S levels compared to COVID-19 patients who survived. Receiver-operating characteristic analysis of NO and H2S metabolites in the study population showed free sulfide levels to be highly predictive of COVID-19 infection based on reduced availability. Traditional determinants of gasotransmitters, namely age, race, sex, diabetes, and hypertension had no effect on NO and H2S levels in COVID-19 patients.
These observations provide the first insight into the role of NO and H2S in COVID-19 infection, where their low availability may be a result of reduced synthesis secondary to endotheliitis, or increased consumption from scavenging of reactive oxygen species.
•NO and H2S availability is decreased in COVID-19 patients compared to healthy controls.•Decreased NO and H2S availability in COVID-19 patients is independent of race, other demographics and comorbidities.•Decreased NO levels in COVID-19 patients parallel an increase in nitrotyrosine, an oxidative stress marker.
Details
- Title: Subtitle
- Decreased availability of nitric oxide and hydrogen sulfide is a hallmark of COVID-19
- Creators
- Paari Dominic - Louisiana State University Health Sciences Center ShreveportJavaria Ahmad - Louisiana State University Health Sciences Center ShreveportRuchi Bhandari - West Virginia UniversitySibile Pardue - Louisiana State University Health Sciences Center ShreveportJuan Solorzano - Louisiana State University Health Sciences Center ShreveportKeerthish Jaisingh - Louisiana State University Health Sciences Center ShreveportMegan Watts - Louisiana State University Health Sciences Center ShreveportSteven R. Bailey - Louisiana State University Health Sciences Center ShreveportA. Wayne Orr - Louisiana State University Health Sciences Center ShreveportChristopher G. Kevil - Louisiana State University Health Sciences Center ShreveportGopi K. Kolluru - Louisiana State University Health Sciences Center Shreveport
- Resource Type
- Journal article
- Publication Details
- Redox biology, Vol.43, pp.101982-101982
- DOI
- 10.1016/j.redox.2021.101982
- PMID
- 34020311
- PMCID
- PMC8106525
- NLM abbreviation
- Redox Biol
- ISSN
- 2213-2317
- eISSN
- 2213-2317
- Publisher
- Elsevier B.V
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100012612, name: LSU Health Shreveport; DOI: 10.13039/100000057, name: National Institute of General Medical Sciences
- Language
- English
- Date published
- 07/2021
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984367238002771
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