Journal article
Decreased blood pressure in NOX1-deficient mice
FEBS letters, Vol.580(2), pp.497-504
2006
DOI: 10.1016/j.febslet.2005.12.049
PMID: 16386251
Abstract
To understand the role of the superoxide-generating NADPH oxidase NOX1 in the vascular system, we have generated NOX1-deficient mice. NOX1-deficient mice had a moderately decreased basal blood pressure. In response to angiotensin II they showed an almost complete loss of the sustained blood pressure response, while the initial increase was conserved. NOX1-deficient mice showed a marked reduction in aortic media hypertrophy. Angiotensin II-induced smooth muscle cell proliferation was conserved, but there was a marked decrease in extracellular matrix accumulation. Our results establish a role for NOX1 in blood pressure regulation and vascular angiotensin II response.
Details
- Title: Subtitle
- Decreased blood pressure in NOX1-deficient mice
- Creators
- Gaetan Gavazzi - University of GenevaBotond Banfi - University of IowaChristine Deffert - University of GenevaLaurence Fiette - University of GenevaMichela Schappi - University of GenevaFrancois Herrmann - University of GenevaKarl-Heinz Krause - University of Geneva
- Resource Type
- Journal article
- Publication Details
- FEBS letters, Vol.580(2), pp.497-504
- DOI
- 10.1016/j.febslet.2005.12.049
- PMID
- 16386251
- NLM abbreviation
- FEBS Lett
- ISSN
- 0014-5793
- eISSN
- 1873-3468
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 2006
- Academic Unit
- Anatomy and Cell Biology; Otolaryngology; Internal Medicine
- Record Identifier
- 9984284345802771
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