Decreased outflow facility and Schlemm?s canal defects in a mouse model of glaucoma

Timur A. Mavlyutov; Megan S. Kuhn; Samer E. Bilal; Michael L. De Ieso; Anil K. Chauhan; W. Daniel Stamer; Colleen M. McDowell

doi:10.1016/j.exer.2022.109249

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Decreased outflow facility and Schlemm?s canal defects in a mouse model of glaucoma

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Decreased outflow facility and Schlemm?s canal defects in a mouse model of glaucoma

Timur A. Mavlyutov, Megan S. Kuhn, Samer E. Bilal, Michael L. De Ieso, Anil K. Chauhan, W. Daniel Stamer and Colleen M. McDowell

Experimental eye research, Vol.225, 109249

12/01/2022

DOI: 10.1016/j.exer.2022.109249

PMCID: PMC9722577

PMID: 36152913

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https://www.ncbi.nlm.nih.gov/pmc/articles/9722577View

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Abstract

Previously we identified B6.EDA+/+ mice as a novel mouse model that presents with elevated IOP and trabecular meshwork damage. Here, we expand on our previous findings by measuring aqueous humor outflow facility and analyzing the integrity of the inner wall of Schlemm???s canal. As expected, intraocular pressure (IOP) was increased, and outflow facility was decreased compared to C57BL/6J controls. B6.EDA+/+ mice had significantly increased expression of the adherens junction protein, VE-cadherin by the inner wall endothelium of Schlemm???s canal. These data suggest that in addition to trabecular meshwork damage, there are changes in Schlemm???s canal in B6.EDA+/+ mice that lead to aqueous outflow dysfunction and ocular hypertension.

Ophthalmology

Life Sciences & Biomedicine

Science & Technology

Details

Title: Subtitle: Decreased outflow facility and Schlemm?s canal defects in a mouse model of glaucoma
Creators: Timur A. Mavlyutov - University of Wisconsin–Madison
Megan S. Kuhn - Duke University
Samer E. Bilal - University of Wisconsin–Madison
Michael L. De Ieso - Duke University
Anil K. Chauhan - University of Iowa
W. Daniel Stamer - Duke University
Colleen M. McDowell - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Experimental eye research, Vol.225, 109249
DOI: 10.1016/j.exer.2022.109249
PMID: 36152913
PMCID: PMC9722577
NLM abbreviation: Exp Eye Res
ISSN: 0014-4835
eISSN: 1096-0007
Publisher: Elsevier
Number of pages: 3
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: P30 EY016665, P30EY005722, R01EY022359, R01EY02652, R01EY028608; DOI: 10.13039/100001818, name: Research to Prevent Blindness; DOI: 10.13039/100006510, name: Duke University
Language: English
Date published: 12/01/2022
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9984359695302771

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