Journal article
Dedifferentiation in the visual cortex: An fMRI investigation of individual differences in older adults
Brain research, Vol.1244, pp.121-131
2008
DOI: 10.1016/j.brainres.2008.09.051
PMID: 18848823
Abstract
Dedifferentiation, or decreased processing specificity, has been suggested to represent a ubiquitous characteristic of cognitive aging. In this study, we examined both age-related differences and intra-group differences in neural specificity in the ventral visual cortex for color, words, faces and places. Our results demonstrated that neural dedifferentiation was not ubiquitous across stimulus categories. Neural dedifferentiation was also relatively stable, across age, in a group of older adults. Older adults with more overall gray matter showed less neural dedifferentiation in the visual cortex. However, regional gray matter volume was not associated with neural dedifferentiation. We illustrate these effects using a discriminability metric, a signal detection theory measure, for neural dedifferentiation that takes into account both magnitude and variance of brain activation. The dedifferentiation measure provides a quantitative means to examine activation patterns and individual difference factors associated with neural dedifferentiation, and to test theories of behavioral dedifferentiation in cognitive aging literature.
Details
- Title: Subtitle
- Dedifferentiation in the visual cortex: An fMRI investigation of individual differences in older adults
- Creators
- Michelle W Voss - Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, USAKirk I Erickson - Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, USALaura Chaddock - Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, USARuchika S Prakash - Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, USAStanley J Colcombe - Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, USAKatherine S Morris - Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 906 South Goodwin Avenue, Urbana, IL 61801, USAShawna Doerksen - Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 906 South Goodwin Avenue, Urbana, IL 61801, USALiang Hu - Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 906 South Goodwin Avenue, Urbana, IL 61801, USAEdward McAuley - Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 906 South Goodwin Avenue, Urbana, IL 61801, USAArthur F Kramer - Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, USA
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.1244, pp.121-131
- DOI
- 10.1016/j.brainres.2008.09.051
- PMID
- 18848823
- NLM abbreviation
- Brain Res
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 2008
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002372302771
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