Journal article
Deep Gray Matter Involvement on Brain MRI Scans Is Associated with Clinical Progression in Multiple Sclerosis
Journal of neuroimaging, Vol.19(1), pp.3-8
01/01/2009
DOI: 10.1111/j.1552-6569.2008.00296.x
PMCID: PMC2762230
PMID: 19192042
Abstract
Conventional brain MRI lesion measures have unreliable associations with clinical progression in multiple sclerosis (MS). Gray matter imaging may improve clinical-MRI correlations.
We tested if gray matter MRI measures and conventional measures of lesions/atrophy predicted clinical progression in a 4-year longitudinal study of 97 patients with MS. Baseline and follow-up brain MRI were analyzed for basal ganglia and thalamic normalized T2 signal intensity, whole brain T2-hyperintense lesion volume, and whole brain atrophy. Logistic regression tested the ability of baseline or on-study change in MRI to predict disability progression, as reported by area under the receiver operator characteristics curve (AUC).
Lower caudate T2-intensity at baseline (P = .04; AUC = .69) and on-study decreasing T2-intensity in the putamen (P = .03; AUC = .70) and thalamus (P = .01; AUC = .71) were the MRI variables associated with clinical progression when regression modeling was adjusted for length of follow-up interval, baseline EDSS, disease duration, age, and sex.
Gray matter T2-hypointensity, suggestive of excessive iron deposition is associated with worsening disability in patients with MS. Gray matter MRI assessment may be able to capture neurodegenerative aspects of the disease, with more clinical relevance than derived from conventional MRI measures.
J Neuroimaging 2009;19:3-8.
Details
- Title: Subtitle
- Deep Gray Matter Involvement on Brain MRI Scans Is Associated with Clinical Progression in Multiple Sclerosis
- Creators
- Mohit Neema - Massachusetts General HospitalAshish Arora - Massachusetts General HospitalBrian C. Healy - Brigham and Women's HospitalZachary D. Guss - Brigham and Women's HospitalSteven D. Brass - Massachusetts General HospitalYang Duan - Harvard UniversityGuy J. Buckle - Brigham and Women's HospitalBonnie I. Glanz - Brigham and Women's HospitalLynn Stazzone - Massachusetts General HospitalSamia J. Khoury - Brigham and Women's HospitalHoward L. Weiner - Brigham and Women's HospitalCharles R. G. Guttmann - Massachusetts General HospitalRohit Bakshi - Massachusetts General Hospital
- Resource Type
- Journal article
- Publication Details
- Journal of neuroimaging, Vol.19(1), pp.3-8
- DOI
- 10.1111/j.1552-6569.2008.00296.x
- PMID
- 19192042
- PMCID
- PMC2762230
- NLM abbreviation
- J Neuroimaging
- ISSN
- 1051-2284
- eISSN
- 1552-6569
- Publisher
- Wiley
- Number of pages
- 6
- Grant note
- NIH-NINDS K23 NS42379-01; R01 NS055083-01 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA K23NS042379 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) RG3705A1; RG3798A2 / National Multiple Sclerosis Society
- Language
- English
- Date published
- 01/01/2009
- Academic Unit
- Psychiatry
- Record Identifier
- 9984627213102771
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