Deep brain stimulation for substance use disorder: a systematic review and meta-analysis

Nour Shaheen; Ahmed Shaheen; Can Sarica; Arun Singh; Mario Zanaty; Karim Johari; Andrew Yang; Theresa Zesiewicz; Brian Dalm; Yarema Bezchlibnyk; Andres M. Lozano; Oliver Flouty

doi:10.3389/fpsyt.2023.1231760

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Deep brain stimulation for substance use disorder: a systematic review and meta-analysis

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Deep brain stimulation for substance use disorder: a systematic review and meta-analysis

Nour Shaheen, Ahmed Shaheen, Can Sarica, Arun Singh, Mario Zanaty, Karim Johari, Andrew Yang, Theresa Zesiewicz, Brian Dalm, Yarema Bezchlibnyk, …

Frontiers in psychiatry, Vol.14, pp.1231760-1231760

08/10/2023

DOI: 10.3389/fpsyt.2023.1231760

PMCID: PMC10449586

PMID: 37636824

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Abstract

Objective: Substance use disorder (SUD) is a significant public health issue with a high mortality rate. Deep brain stimulation (DBS) has shown promising results in treating SUD in certain cases. In this study, we conducted a meta-analysis to evaluate the efficacy of DBS in the treatment of SUD and reduction of relapse rates.Methods: We performed a thorough and methodical search of the existing scientific literature, adhering to the PRISMA guidelines, to identify 16 original studies that fulfilled our inclusion criteria. We used the evidence levels recommended by the Oxford Centre for Evidence-Based Medicine to assess bias. The R version 4.2.3 software was utilized to calculate the mean effect size. We estimated study heterogeneity by employing tau2 and I2 indices and conducting Cochran's Q test.Results: The results showed that DBS treatment resulted in a significant improvement in the clinical SUD scales of patients, with an average improvement of 59.6%. The observed relapse rate was 8%. The meta-analysis estimated a mean effect size of 55.9 [40.4; 71.4]. Heterogeneity analysis showed a large degree of heterogeneity among the included studies. Subgroup and meta-regression analysis based on age and SUD type suggested that DBS may be more effective for patients above 45 years of age, and for alcohol and opioid addiction compared to nicotine addiction.Conclusion: The current literature suggests that DBS has a moderate effect on SUD symptoms. However, the limited number of studies and small sample size indicate that more research is needed to better understand the factors that influence its effectiveness.

Psychiatry

Life Sciences & Biomedicine

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Details

Title: Subtitle: Deep brain stimulation for substance use disorder: a systematic review and meta-analysis
Creators: Nour Shaheen - Alexandria University
Ahmed Shaheen - Alexandria University
Can Sarica - University of Toronto
Arun Singh - University of South Dakota
Mario Zanaty - Jefferson University Hospitals
Karim Johari - Louisiana State University
Andrew Yang - University of Toronto
Theresa Zesiewicz - University of South Florida
Brian Dalm - The Ohio State University
Yarema Bezchlibnyk - University of South Florida
Andres M. Lozano - University of Toronto
Oliver Flouty - University of South Florida
Resource Type: Journal article
Publication Details: Frontiers in psychiatry, Vol.14, pp.1231760-1231760
DOI: 10.3389/fpsyt.2023.1231760
PMID: 37636824
PMCID: PMC10449586
NLM abbreviation: Front Psychiatry
ISSN: 1664-0640
eISSN: 1664-0640
Publisher: Frontiers Media Sa
Number of pages: 12
Grant note: Department of Neurosurgery at the University of South Florida This study was funded by the Department of Neurosurgery at the University of South Florida.
Language: English
Date published: 08/10/2023
Academic Unit: Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984526360002771

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