Deferoxamine-induced electronegative ERG responses

Ruben Jauregui; Karen Sophia Park; Alexander G Bassuk; Vinit B Mahajan; Stephen H Tsang

doi:10.1007/s10633-018-9640-3

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Deferoxamine-induced electronegative ERG responses

Journal article

Peer reviewed

Deferoxamine-induced electronegative ERG responses

Ruben Jauregui, Karen Sophia Park, Alexander G Bassuk, Vinit B Mahajan and Stephen H Tsang

Documenta ophthalmologica, Vol.137(1), pp.15-23

08/2018

DOI: 10.1007/s10633-018-9640-3

PMID: 29770904

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Abstract

To report a case of deferoxamine-induced retinopathy characterized by electroretinography (ERG), optical coherence tomography angiography (OCT-A), and other multimodal imaging. This is an observational case report of one patient. Full-field ERG was performed. OCT-A, spectral-domain optical coherence tomography (SD-OCT), color fundus photography, and fundus autofluorescence were used to characterize the retinopathy induced by deferoxamine use. A 64-year-old man with a history of β-thalassemia intermedia presented with worsening visual acuity, nyctalopia, and electronegative ERG. OCT-A revealed atrophy of the choriocapillaris in areas of hypoautofluorescence, corresponding to regions of retinal atrophy. SD-OCT showed disruption of the ellipsoid zone, granular hyperreflective deposits within the retinal pigment epithelium, thinning of the retinal layers, and extensive choroidal sclerosis and atrophy of the retinal pigment epithelium. Deferoxamine-induced retinopathy can manifest with electronegative maximal ERG responses, and OCT-A can be used to detect deferoxamine toxicity.

Retinal Diseases - diagnosis

Iron Overload - prevention & control

Night Blindness - chemically induced

Humans

Middle Aged

Night Blindness - diagnosis

Retinal Diseases - chemically induced

Male

Siderophores - toxicity

Tomography, Optical Coherence - methods

Atrophy

Multimodal Imaging

Retinal Pigment Epithelium - pathology

Electroretinography - drug effects

Visual Acuity - drug effects

Night Blindness - physiopathology

Retinal Diseases - physiopathology

Deferoxamine - toxicity

Fluorescein Angiography

Retinal Pigment Epithelium - drug effects

Details

Title: Subtitle: Deferoxamine-induced electronegative ERG responses
Creators: Ruben Jauregui - Weill Cornell Medical College, New York, NY, USA
Karen Sophia Park - Jonas Children's Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory, New York, NY, USA
Alexander G Bassuk - Department of Pediatrics, University of Iowa, Iowa City, IA, USA
Vinit B Mahajan - Palo Alto Veterans Administration, Palo Alto, CA, USA
Stephen H Tsang - Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, NY, 10032, USA. sht2@cumc.columbia.edu
Resource Type: Journal article
Publication Details: Documenta ophthalmologica, Vol.137(1), pp.15-23
Publisher: Netherlands
DOI: 10.1007/s10633-018-9640-3
PMID: 29770904
ISSN: 0012-4486
eISSN: 1573-2622
Grant note: P30EY026877 / National Institutes of Health (US) R21AG050437 / NIH HHS R01EY026682 / National Institutes of Health (US) 5P30CA013696 / NCI NIH HHS R21AG050437 / National Institutes of Health (US) R01EY018213 / NIH HHS P30EY019007 / NIH HHS R01Y025225 / NIH HHS R01EY024698 / NIH HHS R01EY024665 / NIH HHS
Language: English
Date published: 08/2018
Academic Unit: Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
Record Identifier: 9984070601202771

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