Journal article
Deficiency of a glycoprotein component of the dystrophin complex in dystrophic muscle
Nature (London), Vol.345(6273), pp.315-319
05/1990
DOI: 10.1038/345315a0
PMID: 2188135
Abstract
Dystrophin, the protein encoded by the Duchenne muscular dystrophy (DMD) gene, exists in a large oligomeric complex. We show here that four glycoproteins are integral components of the dystrophin complex and that the concentration of one of these is greatly reduced in DMD patients. Thus, the absence of dystrophin may lead to the loss of a dystrophin-associated glycoprotein, and the reduction in this glycoprotein may be one of the first stages of the molecular pathogenesis of muscular dystrophy.
Details
- Title: Subtitle
- Deficiency of a glycoprotein component of the dystrophin complex in dystrophic muscle
- Creators
- James M ErvastiKay OhlendieckSteven D KahlMitchell G GaverKevin P Campbell
- Resource Type
- Journal article
- Publication Details
- Nature (London), Vol.345(6273), pp.315-319
- DOI
- 10.1038/345315a0
- PMID
- 2188135
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- Language
- English
- Date published
- 05/1990
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
- Record Identifier
- 9984020779602771
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