Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features

Chella Kamarajan; Ashwini K Pandey; David B Chorlian; Niklas Manz; Arthur T Stimus; Andrey P Anokhin; Lance O Bauer; Samuel Kuperman; John Kramer; Kathleen K Bucholz; Marc A Schuckit; Victor M Hesselbrock; Bernice Porjesz

doi:10.1371/journal.pone.0142659

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Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features

Journal article

Open access

Peer reviewed

Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features

Chella Kamarajan, Ashwini K Pandey, David B Chorlian, Niklas Manz, Arthur T Stimus, Andrey P Anokhin, Lance O Bauer, Samuel Kuperman, John Kramer, Kathleen K Bucholz, …

PloS one, Vol.10(11), pp.e0142659-e0142659

2015

DOI: 10.1371/journal.pone.0142659

PMCID: PMC4651365

PMID: 26580209

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Abstract

Individuals at high risk to develop alcoholism often manifest neurocognitive deficits as well as increased impulsivity. Event-related oscillations (EROs) have been used to effectively measure brain (dys)function during cognitive tasks in individuals with alcoholism and related disorders and in those at risk to develop these disorders. The current study examines ERO theta power during reward processing as well as impulsivity in adolescent and young adult subjects at high risk for alcoholism. EROs were recorded during a monetary gambling task (MGT) in 12-25 years old participants (N = 1821; males = 48%) from high risk alcoholic families (HR, N = 1534) and comparison low risk community families (LR, N = 287) from the Collaborative Study on the Genetics of Alcoholism (COGA). Impulsivity scores and prevalence of externalizing diagnoses were also compared between LR and HR groups. HR offspring showed lower theta power and decreased current source density (CSD) activity than LR offspring during loss and gain conditions. Younger males had higher theta power than younger females in both groups, while the older HR females showed more theta power than older HR males. Younger subjects showed higher theta power than older subjects in each comparison. Differences in topography (i.e., frontalization) between groups were also observed. Further, HR subjects across gender had higher impulsivity scores and increased prevalence of externalizing disorders compared to LR subjects. As theta power during reward processing is found to be lower not only in alcoholics, but also in HR subjects, it is proposed that reduced reward-related theta power, in addition to impulsivity and externalizing features, may be related in a predisposition to develop alcoholism and related disorders.

Electroencephalography

Adolescent

Adult

Alcoholics - psychology

Alcoholism - genetics

Alcoholism - physiopathology

Alcoholism - psychology

Brain - physiopathology

Brain Mapping

Child

Cognition - physiology

Evoked Potentials

Female

Gambling - psychology

Humans

Impulsive Behavior - physiology

Male

Reward

Risk Assessment

Theta Rhythm

Young Adult

Details

Title: Subtitle: Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features
Creators: Chella Kamarajan - SUNY Downstate Health Sciences University
Ashwini K Pandey - SUNY Downstate Health Sciences University
David B Chorlian - SUNY Downstate Health Sciences University
Niklas Manz - SUNY Downstate Health Sciences University
Arthur T Stimus - SUNY Downstate Health Sciences University
Andrey P Anokhin - Washington University in St. Louis
Lance O Bauer - UConn Health
Samuel Kuperman - University of Iowa
John Kramer - University of Iowa
Kathleen K Bucholz - Washington University in St. Louis
Marc A Schuckit - University of California San Diego
Victor M Hesselbrock - UConn Health
Bernice Porjesz - SUNY Downstate Health Sciences University
Resource Type: Journal article
Publication Details: PloS one, Vol.10(11), pp.e0142659-e0142659
DOI: 10.1371/journal.pone.0142659
PMID: 26580209
PMCID: PMC4651365
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Grant note: R01 AA005524 / NIAAA NIH HHS F31 AA005524 / NIAAA NIH HHS P60 AA003510 / NIAAA NIH HHS AA05524 / NIAAA NIH HHS U10AA008401 / NIAAA NIH HHS R37 AA005524 / NIAAA NIH HHS U10 AA008401 / NIAAA NIH HHS
Language: English
Date published: 2015
Academic Unit: Psychiatry
Record Identifier: 9984293652702771

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