Journal article
Deficits in Visual System Functional Connectivity after Blast-Related Mild TBI are Associated with Injury Severity and Executive Dysfunction
Brain and behavior, Vol.6(5), pp.e00454-n/a
05/2016
DOI: 10.1002/brb3.454
PMCID: PMC4873652
PMID: 27257516
Abstract
Approximately, 275,000 American service members deployed to Iraq or Afghanistan have sustained a mild traumatic brain injury (mTBI), with 75% of these incidents involving an explosive blast. Visual processing problems and cognitive dysfunction are common complaints following blast-related mTBI. In 127 veterans, we examined resting fMRI functional connectivity (FC) of four key nodes within the visual system: lateral geniculate nucleus (LGN), primary visual cortex (V1), lateral occipital gyrus (LO), and fusiform gyrus (FG). Regression analyses were performed (i) to obtain correlations between time-series from each seed and all voxels in the brain, and (ii) to identify brain regions in which FC variability was related to blast mTBI severity. Blast-related mTBI severity was quantified as the sum of the severity scores assigned to each of the three most significant blast-related injuries self-reported by subjects. Correlations between FC and performance on executive functioning tasks were performed across participants with available behavioral data (n = 94). Greater blast mTBI severity scores were associated with lower FC between: (A) LGN seed and (i) medial frontal gyrus, (ii) lingual gyrus, and (iii) right ventral anterior nucleus of thalamus; (B) V1 seed and precuneus; (C) LO seed and middle and superior frontal gyri; (D) FG seed and (i) superior and medial frontal gyrus, and (ii) left middle frontal gyrus. Finally, lower FC between visual network regions and frontal cortical regions predicted worse performance on the WAIS digit-symbol coding task. These are the first published results that directly illustrate the relationship between blast-related mTBI severity, visual pathway neural networks, and executive dysfunction - results that highlight the detrimental relationship between blast-related brain injury and the integration of visual sensory input and executive processes.
Details
- Title: Subtitle
- Deficits in Visual System Functional Connectivity after Blast-Related Mild TBI are Associated with Injury Severity and Executive Dysfunction
- Creators
- Casey S Gilmore - Defense and Veterans Brain Injury Center Minneapolis Minnesota; Minneapolis Veterans Affairs Health Care System Minneapolis MinnesotaJazmin Camchong - Department of Psychiatry University of Minnesota Minneapolis MinnesotaNicholas D Davenport - Minneapolis Veterans Affairs Health Care System Minneapolis Minnesota; Department of Psychiatry University of Minnesota Minneapolis MinnesotaNathaniel W Nelson - Minneapolis Veterans Affairs Health Care System Minneapolis Minnesota; Univ. of St. Thomas Graduate School of Professional Psychology Minneapolis MinnesotaRandy H Kardon - Department of Ophthalmology & Visual Science University of Iowa Iowa City Iowa; Iowa City Veterans Affairs Health Care System Iowa City IowaKelvin O Lim - Defense and Veterans Brain Injury Center Minneapolis Minnesota; Minneapolis Veterans Affairs Health Care System Minneapolis Minnesota; Department of Psychiatry University of Minnesota Minneapolis MinnesotaScott R Sponheim - Minneapolis Veterans Affairs Health Care System Minneapolis Minnesota; Department of Psychiatry University of Minnesota Minneapolis Minnesota
- Resource Type
- Journal article
- Publication Details
- Brain and behavior, Vol.6(5), pp.e00454-n/a
- DOI
- 10.1002/brb3.454
- PMID
- 27257516
- PMCID
- PMC4873652
- NLM abbreviation
- Brain Behav
- ISSN
- 2162-3279
- eISSN
- 2162-3279
- Publisher
- United States
- Grant note
- UL1 TR000114 / NCATS NIH HHS I01 RX000622 / RRD VA KL2 TR000113 / NCATS NIH HHS
- Language
- English
- Date published
- 05/2016
- Academic Unit
- Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
- Record Identifier
- 9983980084702771
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