Journal article
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group
Molecular psychiatry, Vol.30(12), pp.6144-6154
12/2025
DOI: 10.1038/s41380-025-03271-y
PMCID: PMC12602352
PMID: 40999039
Abstract
Suicidality phenotypes, consisting of suicidal ideation (SI), suicide attempt (SA), and suicide death (SD), are all heritable but present unique challenges in genome-wide association studies (GWAS) due to their individual complexity, overlap with each other and with related self-harm phenotypes, and varying associations with psychiatric disorders. GWAS have uncovered several loci associated with suicidality phenotypes by meta-analyzing data from multiple cohorts. However, combining datasets from many research groups, where each group may use different study designs, phenotyping instruments, and definitions of suicidality phenotypes, presents challenges. Heterogeneity resulting from these differences can limit genetic discovery; harmonizing phenotype definitions to ensure consistency will greatly improve results. Here, we describe a standardized phenotyping protocol that draws on the expertise of a subgroup of clinicians, researchers, and experts from the Psychiatric Genomics Consortium Suicide Working Group to propose consensus definitions for SI, SA, and SD for genetic studies.
Details
- Title: Subtitle
- Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group
- Creators
- Sarah M C Colbert - Icahn School of Medicine at Mount SinaiEric T Monson - University of UtahOle A Andreassen - Oslo University HospitalOlatunde O Ayinde - University of IbadanPeter B Barr - VA NY Harbor Healthcare SystemCosmin A Bejan - Vanderbilt University Medical CenterZuriel Ceja - QIMR Berghofer Medical Research InstituteHilary Coon - University of UtahEmily DiBlasi - University of UtahHoward J Edenberg - Indiana University BloomingtonJoel Gelernter - Yale UniversityAlexander Hatoum - Washington University in St. LouisAnastasia Izotova - University of OsloEmma C Johnson - Washington University in St. LouisErin A Kaufman - University of UtahHenry R Kranzler - University of PennsylvaniaMaria Koromina - Icahn School of Medicine at Mount SinaiKelli Lehto - University of TartuWoojae Myung - Seoul National University Bundang HospitalJohn I Nurnberger Jr - Indiana University School of MedicineAlessandro Serretti - Università degli Studi di Enna KoreJordan W Smoller - Broad InstituteMurray B Stein - University of California San DiegoClement C Zai - Broad InstituteAnnette Erlangsen - Australian National UniversityMarie Gaine - University of IowaLourdes Martorell - Universitat Rovira i VirgiliReeteka Sud - National Institute of Mental Health and NeurosciencesClaudio Toma - Neuroscience Research AustraliaTim B Bigdeli - SUNY Downstate Health Sciences UniversityNathan A Kimbrel - VA Mid-Atlantic Health Care NetworkDouglas Ruderfer - Vanderbilt University Medical CenterAnna R Docherty - University of UtahJ John Mann - Columbia UniversityNiamh Mullins - Icahn School of Medicine at Mount SinaiPsychiatric Genomics Consortium Suicide Working Group
- Resource Type
- Journal article
- Publication Details
- Molecular psychiatry, Vol.30(12), pp.6144-6154
- DOI
- 10.1038/s41380-025-03271-y
- PMID
- 40999039
- PMCID
- PMC12602352
- NLM abbreviation
- Mol Psychiatry
- ISSN
- 1476-5578
- eISSN
- 1476-5578
- Publisher
- Springer Nature
- Grant note
- 1842169 / National Science Foundation (NSF) R01MH132733 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01 MH132733 / NIMH NIH HHS
- Language
- English
- Electronic publication date
- 09/25/2025
- Date published
- 12/2025
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984966331002771
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