Journal article
Defining the risk of SARS-CoV-2 variants on immune protection
Nature (London), Vol.605, pp.640-652
03/31/2022
DOI: 10.1038/s41586-022-04690-5
PMCID: PMC9345323
PMID: 35361968
Abstract
The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants jeopardizes the protective antiviral immunity induced following infection or vaccination. To address the public health threat caused by the increasing SARS-CoV-2 genomic diversity, the National Institute of Allergy and Infectious Diseases (NIAID) within the National Institutes of Health (NIH) established the SARS-CoV-2 Assessment of Viral Evolution (SAVE) program. This effort was designed to provide a real-time risk assessment of SARS-CoV-2 variants potentially impacting transmission, virulence, and resistance to convalescent and vaccine-induced immunity. The SAVE program serves as a critical data-generating component of the United States Government SARS-CoV-2 Interagency Group to assess implications of SARS-CoV-2 variants on diagnostics, vaccines, and therapeutics and for communicating public health risk. Here we describe the coordinated approach used to identify and curate data about emerging variants, their impact on immunity, and effects on vaccine protection using animal models. We report the development of reagents, methodologies, models, and pivotal findings facilitated by this collaborative approach and identify future challenges. This program serves as a template for the response against rapidly evolving pandemic pathogens by monitoring viral evolution in the human population to identify variants that could erode the effectiveness of countermeasures.
Details
- Title: Subtitle
- Defining the risk of SARS-CoV-2 variants on immune protection
- Creators
- Marciela M DeGrace - Division of Microbiology and Infectious Diseases, Rockville, MD, USAElodie Ghedin - Systems Genomics Section, Laboratory of Parasitic Diseases, Rockville, MD, USAMatthew B Frieman - Center for Pathogen Research, The Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, MD, USAFlorian Krammer - Icahn School of Medicine at Mount SinaiAlba Grifoni - Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USAArghavan Alisoltani - University of California, RiversideGalit Alter - Ragon Institute of MGH, MIT and HarvardRama R Amara - Emory University School of MedicineRalph S Baric - University of North Carolina at Chapel HillDan H Barouch - Beth Israel Deaconess Medical CenterJesse D Bloom - Howard Hughes Medical InstituteLouis-Marie Bloyet - Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USAGaston Bonenfant - Centers for Disease Control and PreventionAdrianus C M Boon - Washington University in St. LouisEli A Boritz - Vaccine Research Center, Rockville, MD, USADebbie L Bratt - CAMRIS, Contractor for NIAID, Bethesda, MD, USATraci L Bricker - Washington University in St. LouisLiliana Brown - Division of Microbiology and Infectious Diseases, Rockville, MD, USAWilliam J Buchser - High Throughput Screening Center, Washington University School of Medicine, St. Louis, St. Louis, MO, USAJuan Manuel Carreño - Icahn School of Medicine at Mount SinaiLiel Cohen-Lavi - Ben-Gurion University of the NegevTamarand L Darling - Washington University in St. LouisMeredith E Davis-Gardner - Emory University School of MedicineBethany L Dearlove - Walter Reed Army Institute of ResearchHan Di - Centers for Disease Control and PreventionMeike Dittmann - Microbiology Department, New York University Grossman School of Medicine, New York, NY, USANicole A Doria-Rose - Vaccine Research Center, Rockville, MD, USADaniel C Douek - Vaccine Research Center, Rockville, MD, USAChristian Drosten - German Center for Infection ResearchVenkata-Viswanadh Edara - Emory University School of MedicineAli Ellebedy - Department of Pathology and Immunology Washington University School of Medicine, St. Louis, MO, USAThomas P Fabrizio - St. Jude Children's Research HospitalGuido Ferrari - Duke UniversityWilliam C Florence - Division of Microbiology and Infectious Diseases, Rockville, MD, USARon A M Fouchier - Erasmus MCJohn Franks - St. Jude Children's Research HospitalAdolfo García-Sastre - Icahn School of Medicine at Mount SinaiAdam Godzik - University of California, RiversideAna Silvia Gonzalez-Reiche - Icahn School of Medicine at Mount SinaiAubree Gordon - University of MichiganBart L Haagmans - Erasmus MCPeter J Halfmann - University of Wisconsin–MadisonDavid D Ho - Columbia UniversityMichael R Holbrook - National Institute of Allergy and Infectious DiseasesYaoxing Huang - Columbia UniversitySarah L James - University of CambridgeLukasz Jaroszewski - University of California, RiversideTrushar Jeevan - St. Jude Children's Research HospitalRobert M Johnson - Center for Pathogen Research, The Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, MD, USATerry C Jones - University of CambridgeAstha Joshi - Washington University in St. LouisYoshihiro Kawaoka - Disease Control and Prevention Center, National Center for Global Health and Medicine Hospital, Tokyo, JapanLisa Kercher - St. Jude Children's Research HospitalMarion P G Koopmans - Erasmus MCBette Korber - Los Alamos National LaboratoryEilay Koren - Ben-Gurion University of the NegevRichard A Koup - Vaccine Research Center, Rockville, MD, USAEric B LeGresley - University of CambridgeJacob E Lemieux - Broad InstituteMariel J Liebeskind - High Throughput Screening Center, Washington University School of Medicine, St. Louis, St. Louis, MO, USAZhuoming Liu - Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USABrandi Livingston - St. Jude Children's Research HospitalJames P Logue - Center for Pathogen Research, The Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, MD, USAYang Luo - Columbia UniversityAdrian B McDermott - Vaccine Research Center, Rockville, MD, USAMargaret J McElrath - Fred Hutchinson Cancer Research Center, Seattle, WA, USAVictoria A Meliopoulos - St. Jude Children's Research HospitalVineet D Menachery - Department of Microbiology and Immunology, Institute for Human Infection and Immunity, World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USADavid C Montefiori - Duke UniversityBarbara Mühlemann - University of CambridgeVincent J Munster - National Institute of Allergy and Infectious DiseasesJenny E Munt - University of North Carolina at Chapel HillManoj S Nair - Columbia UniversityAntonia Netzl - University of CambridgeAnna M Niewiadomska - J. Craig Venter InstituteSijy O'Dell - Vaccine Research Center, Rockville, MD, USAAndrew Pekosz - Bloomberg (United States)Stanley Perlman - Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USAMarjorie C Pontelli - Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USABarry Rockx - Erasmus MCMorgane Rolland - Walter Reed Army Institute of ResearchPaul W Rothlauf - Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USASinai Sacharen - Ben-Gurion University of the NegevRichard H Scheuermann - J. Craig Venter InstituteStephen D Schmidt - Vaccine Research Center, Rockville, MD, USAMichael Schotsaert - Icahn School of Medicine at Mount SinaiStacey Schultz-Cherry - St. Jude Children's Research HospitalRobert A Seder - Vaccine Research Center, Rockville, MD, USAMayya Sedova - University of California, RiversideAlessandro Sette - University of California San DiegoReed S Shabman - Division of Microbiology and Infectious Diseases, Rockville, MD, USAXiaoying Shen - Duke UniversityPei-Yong Shi - Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX, USAMaulik Shukla - Argonne National LaboratoryViviana Simon - Icahn School of Medicine at Mount SinaiSpencer Stumpf - Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USANancy J Sullivan - Vaccine Research Center, Rockville, MD, USALarissa B Thackray - Departments of Medicine, Washington University School of Medicine, St. Louis, MO, USAJames Theiler - Los Alamos National LaboratoryPaul G Thomas - St. Jude Children's Research HospitalSanja Trifkovic - St. Jude Children's Research HospitalSina Türeli - University of CambridgeSamuel A Turner - University of CambridgeMaria A Vakaki - High Throughput Screening Center, Washington University School of Medicine, St. Louis, St. Louis, MO, USAHarm van Bakel - Icahn School of Medicine at Mount SinaiLaura A VanBlargan - Departments of Medicine, Washington University School of Medicine, St. Louis, MO, USALeah R Vincent - Division of Microbiology and Infectious Diseases, Rockville, MD, USAZachary S Wallace - University of California San DiegoLi Wang - Centers for Disease Control and PreventionMaple Wang - Columbia UniversityPengfei Wang - Columbia UniversityWei Wang - Center for Biologics Evaluation and ResearchScott C Weaver - Department of Microbiology and Immunology, Institute for Human Infection and Immunity, World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USARichard J Webby - St. Jude Children's Research HospitalCarol D Weiss - Center for Biologics Evaluation and ResearchDavid E Wentworth - Centers for Disease Control and PreventionStuart M Weston - Center for Pathogen Research, The Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, MD, USASean P J Whelan - Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USABradley M Whitener - Departments of Medicine, Washington University School of Medicine, St. Louis, MO, USASamuel H Wilks - University of CambridgeXuping Xie - Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX, USABaoling Ying - Departments of Medicine, Washington University School of Medicine, St. Louis, MO, USAHyejin Yoon - Los Alamos National LaboratoryBin Zhou - Centers for Disease Control and PreventionTomer Hertz - Ben-Gurion University of the NegevDerek J Smith - University of CambridgeMichael S Diamond - Departments of Medicine, Molecular Microbiology, Pathology & Immunology, The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA. mdiamond@wustl.eduDiane J Post - Division of Microbiology and Infectious Diseases, Rockville, MD, USA. postd@niaid.nih.govMehul S Suthar - Emory University School of Medicine
- Resource Type
- Journal article
- Publication Details
- Nature (London), Vol.605, pp.640-652
- DOI
- 10.1038/s41586-022-04690-5
- PMID
- 35361968
- PMCID
- PMC9345323
- NLM abbreviation
- Nature
- eISSN
- 1476-4687
- Language
- English
- Date published
- 03/31/2022
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
- Record Identifier
- 9984230416102771
Metrics
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