Journal article
Defining the role of common variation in the genomic and biological architecture of adult human height
Nature genetics, Vol.46(11), pp.1173-1186
11/2014
DOI: 10.1038/ng.3097
PMCID: PMC4250049
PMID: 25282103
Abstract
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.
Details
- Title: Subtitle
- Defining the role of common variation in the genomic and biological architecture of adult human height
- Creators
- Andrew R Wood - Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UKPekka Jousilahti - National Institute for Health and Welfare, Helsinki, FinlandPamela A F Madden - Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USAAntti M Jula - National Institute for Health and Welfare, Helsinki, FinlandJaakko Kaprio - 1] National Institute for Health and Welfare, Helsinki, Finland. Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland. Hjelt Institute Department of Public Health, University of Helsinki, Helsinki, FinlandJeffrey Baron - Section on Growth and Development, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, US National Institutes of Health, Bethesda, Maryland, USASatu Männistö - National Institute for Health and Welfare, Helsinki, FinlandJohn J P Kastelein - Department of Vascular Medicine, Academic Medical Center, Amsterdam, the NetherlandsManfred Kayser - 1] Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands. Department of Forensic Molecular Biology, Erasmus Medical Center, Rotterdam, the NetherlandsJeffrey C Murray - Department of Pediatrics, University of Iowa, Iowa City, Iowa, USAPaolo Manunta - 1] Division of Nephrology and Dialysis, San Raffaele Scientific Institute, Milan, Italy. Università Vita-Salute San Raffaele, Milan, ItalyFrank Kee - UK Clinical Research Collaboration Centre of Excellence for Public Health (Northern Ireland), Queens University of Belfast, Belfast, UKTonu Esko - 1] Estonian Genome Center, University of Tartu, Tartu, Estonia. Division of Endocrinology, Genetics and Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA. Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USASirkka M Keinanen-Kiukaanniemi - 1] Faculty of Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland. Unit of General Practice, Oulu University Hospital, Oulu, FinlandLambertus A Kiemeney - 1] Department for Health Evidence, Radboud University Medical Centre, Nijmegen, the Netherlands. Department of Urology, Radboud University Medical Centre, Nijmegen, the NetherlandsAndré Marette - 1] Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada. Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, CanadaTara C Matise - Department of Genetics, Rutgers University, Piscataway, New Jersey, USAJaspal S Kooner - 1] Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK. Imperial College Healthcare NHS Trust, London, UK. National Heart and Lung Institute, Imperial College London, London, UKCharles Kooperberg - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USAJian Yang - 1] Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, Queensland, AustraliaAndrew P Morris - 1] Estonian Genome Center, University of Tartu, Tartu, Estonia. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Department of Biostatistics, University of Liverpool, Liverpool, UKSeppo Koskinen - National Institute for Health and Welfare, Helsinki, FinlandSailaja Vedantam - 1] Division of Endocrinology, Genetics and Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA. Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USAPeter Kovacs - 1] Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany. Department of Medicine, University of Leipzig, Leipzig, GermanyAldi T Kraja - Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USAJian'an Luan - Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UKMartin L Buchkovich - Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USAAlbertine J Oldehinkel - Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the NetherlandsBarbara McKnight - Department of Biostatistics, University of Washington, Seattle, Washington, USAMeena Kumari - Department of Epidemiology and Public Health, University College London, London, UKMari Nelis - Estonian Genome Center, University of Tartu, Tartu, EstoniaKen K Ong - 1] Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. MRC Unit for Lifelong Health and Ageing at University College London, London, UKDamien C Croteau-Chonka - 1] Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USAJohanna Kuusisto - Department of Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, FinlandFrans L Moll - Department of Surgery, University Medical Center Utrecht, Utrecht, the NetherlandsWillem H Ouwehand - 1] Department of Haematology, University of Cambridge, Cambridge, UK. NHS Blood and Transplant, Cambridge, UKStefan Gustafsson - 1] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, SwedenTimo A Lakka - 1] Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, FinlandZoltán Kutalik - 1] Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. Swiss Institute of Bioinformatics, Lausanne, Switzerland. Department of Medical Genetics, University of Lausanne, Lausanne, SwitzerlandFelix R Day - Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UKClaudia Langenberg - 1] Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Department of Epidemiology and Public Health, University College London, London, UKAudrey Y Chu - Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USAYanan Duan - Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, USAClaes Ohlsson - Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenGerard Pasterkamp - Experimental Cardiology Laboratory, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the NetherlandsLoic Le Marchand - Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USATune H Pers - 1] Division of Endocrinology, Genetics and Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA. Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, DenmarkAnnette Peters - 1] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany. Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyGrant W Montgomery - QIMR Berghofer Medical Research Institute, Brisbane, Queensland, AustraliaTove Fall - 1] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenKarol Estrada - 1] Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USATerho Lehtimäki - Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, FinlandNajaf Amin - Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the NetherlandsRudolf Fehrmann - Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsAnne U Jackson - Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USAPeter P Pramstaller - 1] Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck, Lübeck, Germany). Department of Neurology, General Central Hospital, Bolzano, ItalyAndrew D Morris - Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UKJuha Karjalainen - Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsSara Lupoli - 1] Department of Health Sciences, University of Milano, Milan, Italy. Fondazione Filarete, Milan, ItalyThomas Meitinger - DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), Munich Heart Alliance, Munich, GermanyTeresa Ferreira - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UKJackie F Price - Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UKKen Sin Lo - Montreal Heart Institute, Montreal, Quebec, CanadaAdam E Locke - Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USAReedik Mägi - 1] Estonian Genome Center, University of Tartu, Tartu, Estonia. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UKEvelin Mihailov - 1] Estonian Genome Center, University of Tartu, Tartu, Estonia. Institute of Molecular and Cell Biology, University of Tartu, Tartu, EstoniaEleonora Porcu - Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, ItalyJoshua C Randall - 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Wellcome Trust Sanger Institute, Hinxton, UKAndré Scherag - 1] Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany. Clinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, GermanyAnna A E Vinkhuyzen - Queensland Brain Institute, University of Queensland, Brisbane, Queensland, AustraliaHarm-Jan Westra - Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsThomas W Winkler - Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, GermanyTsegaselassie Workalemahu - Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USAJing Hua Zhao - Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UKDevin Absher - HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USAEva Albrecht - Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyDenise Anderson - Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, AustraliaMarian Beekman - 1] Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden, the Netherlands. Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the NetherlandsAyse Demirkan - 1] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. Department of Human Genetics, Leiden University Medical Center, Leiden, the NetherlandsGeorg B Ehret - 1] Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Department of Specialties of Internal Medicine, Division of Cardiology, Geneva University Hospital, Geneva, SwitzerlandBjarke Feenstra - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkMary F Feitosa - Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USAKrista Fischer - Estonian Genome Center, University of Tartu, Tartu, EstoniaRoss M Fraser - Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UKAnuj Goel - 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, UKJian Gong - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USAAnne E Justice - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USAStavroula Kanoni - William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UKMarcus E Kleber - 1] Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany. Department of Internal Medicine II, Ulm University Medical Centre, Ulm, GermanyKati Kristiansson - National Institute for Health and Welfare, Helsinki, FinlandUnhee Lim - Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USAVaneet Lotay - Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USAJulian C Lui - Section on Growth and Development, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, US National Institutes of Health, Bethesda, Maryland, USAMassimo Mangino - Department of Twin Research and Genetic Epidemiology, King's College London, London, UKIrene Mateo Leach - Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsCarolina Medina-Gomez - 1] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands. Department of Epidemiology, Erasmus Medical Center, Rotterdam, the NetherlandsMichael A Nalls - Laboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USADale R Nyholt - QIMR Berghofer Medical Research Institute, Brisbane, Queensland, AustraliaCameron D Palmer - 1] Division of Endocrinology, Genetics and Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA. Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USADorota Pasko - Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UKSonali Pechlivanis - Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, GermanyStefania Bandinelli - Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, ItalyInga Prokopenko - 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UKAmy Barrett - Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UKJanina S Ried - Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyClaire Bellis - Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USAStephan Ripke - 1] Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USAAmanda J Bennett - Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UKChristian Berne - Department of Medical Sciences, Endocrinology, Diabetes and Metabolism, Uppsala University, Uppsala, SwedenDmitry Shungin - 1] Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hospital, Malmö, Sweden. Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, Sweden. Department of Odontology, Umeå University, Umeå, SwedenMatthias Blüher - 1] Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany. Department of Medicine, University of Leipzig, Leipzig, GermanyAlena Stancáková - Department of Medicine, University of Eastern Finland, Kuopio, FinlandRona J Strawbridge - Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, SwedenJennifer L Bolton - Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UKYun Ju Sung - Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USAYvonne Böttcher - Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, GermanyHeather A Boyd - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkToshiko Tanaka - Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, USAAlexander Teumer - Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, GermanyMarcel Bruinenberg - LifeLines, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsBrendan M Buckley - Department of Pharmacology and Therapeutics, University College Cork, Cork, IrelandStella Trompet - 1] Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the NetherlandsSteven Buyske - 1] Department of Statistics and Biostatistics, Rutgers University, Piscataway, New Jersy, USA. Department of Genetics, Rutgers University, Piscataway, New Jersey, USASander W van der Laan - Experimental Cardiology Laboratory, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the NetherlandsJessica van Setten - Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the NetherlandsIda H Caspersen - Department of Biology, Norwegian University of Science and Technology, Trondheim, NorwayJana V Van Vliet-Ostaptchouk - Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the NetherlandsPeter S Chines - Genome Technology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USAZhaoming Wang - 1] DZHK (Deutsches Zentrum für Herz-Kreislaufforschung-German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA. Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USARobert Clarke - Clinical Trial Service Unit, Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UKLoïc Yengo - 1] CNRS UMR 8199, Lille, France. European Genomic Institute for Diabetes, Lille, France. Université de Lille 2, Lille, FranceSimone Claudi-Boehm - Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, Ulm, GermanyMatthew Cooper - Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, AustraliaWeihua Zhang - 1] Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK. Department of Epidemiology and Biostatistics, Imperial College London, London, UKE Warwick Daw - Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USAUzma Afzal - 1] Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK. Department of Epidemiology and Biostatistics, Imperial College London, London, UKJohan Arnlöv - 1] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden. School of Health and Social Studies, Dalarna University, Falun, SwedenPim A De Jong - Department of Radiology, University Medical Center Utrecht, Utrecht, the NetherlandsGraciela Delgado - Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, GermanyJoris Deelen - 1] Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden, the Netherlands. Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the NetherlandsGillian M Arscott - PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia, AustraliaJosh C Denny - Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee, USARosalie Dhonukshe-Rutten - Department of Human Nutrition, Wageningen University, Wageningen, the NetherlandsMaria Dimitriou - Department of Dietetics-Nutrition, Harokopio University, Athens, GreeceAlex S F Doney - Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UKMarcus Dörr - 1] DZHK (Deutsches Zentrum für Herz-Kreislaufforschung-German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. Department of Internal Medicine B, University Medicine Greifswald, Greifswald, GermanyNiina Eklund - 1] National Institute for Health and Welfare, Helsinki, Finland. Institute for Molecular Medicine, University of Helsinki, Helsinki, FinlandElodie Eury - 1] CNRS UMR 8199, Lille, France. European Genomic Institute for Diabetes, Lille, France. Université de Lille 2, Lille, FranceLasse Folkersen - Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, SwedenMelissa E Garcia - Laboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USAFrank Geller - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkVilmantas Giedraitis - Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, SwedenAlan S Go - Kaiser Permanente, Division of Research, Oakland, California, USAHarald Grallert - 1] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. German Center for Diabetes Research (DZD), Neuherberg, GermanyTanja B Grammer - Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, GermanyJürgen Gräßler - Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, GermanyHenrik Grönberg - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenLisette C P G M de Groot - Department of Human Nutrition, Wageningen University, Wageningen, the NetherlandsChristopher J Groves - Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UKJeffrey Haessler - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USAPer Hall - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenToomas Haller - Estonian Genome Center, University of Tartu, Tartu, EstoniaGoran Hallmans - Unit of Nutritional Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, SwedenAnke Hannemann - Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, GermanyCatharina A Hartman - Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the NetherlandsMaija Hassinen - Kuopio Research Institute of Exercise Medicine, Kuopio, FinlandCaroline Hayward - MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UKNancy L Heard-Costa - 1] National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, USA. Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USAQuinta Helmer - 1] Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden, the Netherlands. Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands. Faculty of Psychology and Education, VU University Amsterdam, Amsterdam, the NetherlandsGibran Hemani - 1] Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, Queensland, AustraliaAnjali K Henders - QIMR Berghofer Medical Research Institute, Brisbane, Queensland, AustraliaHans L Hillege - 1] Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsMark A Hlatky - Department of Medicine, Stanford University School of Medicine, Stanford, California, USAWolfgang Hoffmann - 1] DZHK (Deutsches Zentrum für Herz-Kreislaufforschung-German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. Institute for Community Medicine, University Medicine Greifswald, Greifswald, GermanyPer Hoffmann - 1] Department of Biomedicine, Division of Medical Genetics, University of Basel, Basel, Switzerland. Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany. Institute of Human Genetics, University of Bonn, Bonn, GermanyOddgeir Holmen - Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, NorwayJeanine J Houwing-Duistermaat - 1] Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden, the Netherlands. Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the NetherlandsThomas Illig - 1] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Hannover Unified Biobank, Hannover Medical School, Hannover, GermanyAaron Isaacs - 1] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. Center for Medical Systems Biology, Leiden, the NetherlandsAlan L James - 1] Department of Pulmonary Physiology and Sleep Medicine, Nedlands, Western Australia, Australia. School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, AustraliaJanina Jeff - Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USABerit Johansen - Department of Biology, Norwegian University of Science and Technology, Trondheim, NorwayÅsa Johansson - Department of Immunology, Genetics and Pathology, SciLifeLab, Rudbeck Laboratory, Uppsala University, Uppsala, SwedenJennifer Jolley - 1] Department of Haematology, University of Cambridge, Cambridge, UK. NHS Blood and Transplant, Cambridge, UKThorhildur Juliusdottir - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UKJuhani Junttila - Department of Medicine, University of Oulu, Oulu, FinlandAbel N Kho - Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USALeena Kinnunen - National Institute for Health and Welfare, Helsinki, FinlandNorman Klopp - 1] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Hannover Unified Biobank, Hannover Medical School, Hannover, GermanyThomas Kocher - Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Greifswald, GermanyWolfgang Kratzer - Department of Internal Medicine I, Ulm University Medical Centre, Ulm, GermanyPeter Lichtner - Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyLars Lind - Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, SwedenJaana Lindström - National Institute for Health and Welfare, Helsinki, FinlandStéphane Lobbens - 1] CNRS UMR 8199, Lille, France. European Genomic Institute for Diabetes, Lille, France. Université de Lille 2, Lille, FranceMattias Lorentzon - Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenYingchang Lu - 1] Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USAValeriya Lyssenko - Steno Diabetes Center A/S, Gentofte DenmarkPatrik K E Magnusson - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenAnubha Mahajan - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UKMarc Maillard - Service of Nephrology, Department of Medicine, Lausanne University Hospital (CHUV), Lausanne, SwitzerlandWendy L McArdle - School of Social and Community Medicine, University of Bristol, Bristol, UKColin A McKenzie - Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, JamaicaStela McLachlan - Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UKPaul J McLaren - 1] Global Health Institute, Department of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Institute of Microbiology, University Hospital and University of Lausanne, Lausanne, SwitzerlandCristina Menni - Department of Twin Research and Genetic Epidemiology, King's College London, London, UKSigrun Merger - Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, Ulm, GermanyLili Milani - Estonian Genome Center, University of Tartu, Tartu, EstoniaAlireza Moayyeri - Department of Twin Research and Genetic Epidemiology, King's College London, London, UKKeri L Monda - 1] Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Center for Observational Research, Amgen, Inc., Thousand Oaks, California, USAMario A Morken - Genome Technology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USAGabriele Müller - Center for Evidence-Based Healthcare, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, GermanyMartina Müller-Nurasyid - 1] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Department of Medicine I, University Hospital Großhadern, Ludwig Maximilians Universität, Munich, Germany. Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians Universität, Neuherberg, Germany. DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), Munich Heart Alliance, Munich, GermanyArthur W Musk - Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, AustraliaNarisu Narisu - Genome Technology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USAMatthias Nauck - 1] DZHK (Deutsches Zentrum für Herz-Kreislaufforschung-German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, GermanyIlja M Nolte - Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsMarkus M Nöthen - 1] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany. Institute of Human Genetics, University of Bonn, Bonn, GermanyLaticia Oozageer - Ealing Hospital National Health Service (NHS) Trust, Middlesex, UKStefan Pilz - 1] Department of Epidemiology and Biostatistics, Institute for Research in Extramural Medicine (EMGO) Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands. Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, AustriaNigel W Rayner - 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Wellcome Trust Sanger Institute, Hinxton, UK. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UKFrida Renstrom - Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hospital, Malmö, SwedenNeil R Robertson - 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UKLynda M Rose - Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USARonan Roussel - 1] Diabetology-Endocrinology-Nutrition, Public Hospital System of the City of Paris (AP-HP), Bichat Hospital, Paris, France. INSERM U872, Centre de Recherche des Cordeliers, Paris, France. Paris Diderot University, Paris, FranceSerena Sanna - Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, ItalyHubert Scharnagl - Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, AustriaSalome Scholtens - Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsFredrick R Schumacher - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USAHeribert Schunkert - 1] DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany. Deutsches Herzzentrum München, Technische Universität München, Munich, GermanyRobert A Scott - Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UKJoban Sehmi - 1] Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK. Department of Epidemiology and Biostatistics, Imperial College London, London, UKThomas Seufferlein - Department of Internal Medicine I, Ulm University Medical Centre, Ulm, GermanyJianxin Shi - National Cancer Institute, Bethesda, Maryland, USAKarri Silventoinen - Department of Sociology, University of Helsinki, Helsinki, FinlandJohannes H Smit - 1] EMGO Institute for Health and Care Research, VU University, Amsterdam, the Netherlands. Department of Psychiatry, Neuroscience Campus, VU University Amsterdam, Amsterdam, the NetherlandsAlbert Vernon Smith - 1] Icelandic Heart Association, Kopavogur, Iceland. University of Iceland, Reykjavik, IcelandJoanna Smolonska - 1] Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsAlice V Stanton - Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, IrelandKathleen Stirrups - 1] Wellcome Trust Sanger Institute, Hinxton, UK. William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UKDavid J Stott - Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UKHeather M Stringham - Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USAJohan Sundström - Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, SwedenMorris A Swertz - Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsAnn-Christine Syvänen - 1] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala, SwedenBamidele O Tayo - Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois, USAGudmar Thorleifsson - deCODE Genetics, Amgen, Inc., Reykjavik, IcelandJonathan P Tyrer - Department of Oncology, University of Cambridge, Cambridge, UKSuzanne van Dijk - Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the NetherlandsNatasja M van Schoor - Department of Epidemiology and Biostatistics, Institute for Research in Extramural Medicine (EMGO) Institute for Health and Care Research, VU University Medical Center, Amsterdam, the NetherlandsNathalie van der Velde - 1] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. Section of Geriatrics, Department of Internal Medicine, Academic Medical Center, Amsterdam, the NetherlandsDiana van Heemst - 1] Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden, the Netherlands. Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the NetherlandsFloor V A van Oort - Department of Child and Adolescent Psychiatry, Psychology, Erasmus University Medical Center, Rotterdam, the NetherlandsSita H Vermeulen - 1] Department for Health Evidence, Radboud University Medical Centre, Nijmegen, the Netherlands. Department of Genetics, Radboud University Medical Centre, Nijmegen, the NetherlandsNiek Verweij - Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsJudith M Vonk - Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsLindsay L Waite - HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USAMelanie Waldenberger - Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyRoman Wennauer - Department of Clinical Chemistry, Ulm University Medical Centre, Ulm, GermanyLynne R Wilkens - Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USAChristina Willenborg - 1] DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), partner site Hamburg-Lubeck-Kiel, Lubeck, Germany. Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, GermanyTom Wilsgaard - Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Tromsø, Tromsø, NorwayMary K Wojczynski - Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USAAndrew Wong - MRC Unit for Lifelong Health and Ageing at University College London, London, UKAlan F Wright - MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UKQunyuan Zhang - Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USADominique Arveiler - Department of Epidemiology and Public Health, University of Strasbourg, Faculty of Medicine, Strasbourg, FranceStephan J L Bakker - Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsJohn Beilby - 1] PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia, Australia. Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, AustraliaRichard N Bergman - Cedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, California, USASven Bergmann - 1] Swiss Institute of Bioinformatics, Lausanne, Switzerland. Department of Medical Genetics, University of Lausanne, Lausanne, SwitzerlandReiner Biffar - Department of Prosthetic Dentistry, Gerostomatology and Dental Materials, University Medicine Greifswald, Greifswald, GermanyJohn Blangero - Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USADorret I Boomsma - Biological Psychology, VU University Amsterdam, Amsterdam, the NetherlandsStefan R Bornstein - Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, GermanyPascal Bovet - 1] Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland. Ministry of Health, Victoria, Republic of SeychellesPaolo Brambilla - Laboratory Medicine, Hospital of Desio, Department of Health Sciences, University of Milano, Bicocca, ItalyMorris J Brown - Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, UKHarry Campbell - Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UKMark J Caulfield - 1] Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UKAravinda Chakravarti - Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USARory Collins - Clinical Trial Service Unit, Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UKFrancis S Collins - Genome Technology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USADana C Crawford - 1] Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USAL Adrienne Cupples - 1] National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, USA. Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USAJohn Danesh - Department of Public Health and Primary Care, University of Cambridge, Cambridge, UKUlf de Faire - Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenHester M den Ruijter - 1] Experimental Cardiology Laboratory, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the NetherlandsRaimund Erbel - Clinic of Cardiology, West German Heart Centre, University Hospital Essen, Essen, GermanyJeanette Erdmann - 1] DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), partner site Hamburg-Lubeck-Kiel, Lubeck, Germany. Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, GermanyJohan G Eriksson - 1] National Institute for Health and Welfare, Helsinki, Finland. Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland. Unit of General Practice, Helsinki University Central Hospital, Helsinki, FinlandMartin Farrall - 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, UKEle Ferrannini - 1] Department of Internal Medicine, University of Pisa, Pisa, Italy. National Research Council (CNR) Institute of Clinical Physiology, University of Pisa, Pisa, ItalyJean Ferrières - Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, FranceIan Ford - Robertson Center for Biostatistics, University of Glasgow, Glasgow, UKNita G Forouhi - Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UKTerrence Forrester - Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, JamaicaRon T Gansevoort - Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsPablo V Gejman - NorthShore University HealthSystem, University of Chicago, Evanston, Illinois, USAChristian Gieger - Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyAlain Golay - Service of Therapeutic Education for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, Geneva, SwitzerlandOmri Gottesman - Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USAVilmundur Gudnason - 1] Icelandic Heart Association, Kopavogur, Iceland. University of Iceland, Reykjavik, IcelandUlf Gyllensten - Department of Immunology, Genetics and Pathology, SciLifeLab, Rudbeck Laboratory, Uppsala University, Uppsala, SwedenDavid W Haas - Department of Medicine, Pharmacology, Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USAAlistair S Hall - Leeds MRC Medical Bioinformatics Centre, University of Leeds, Leeds, UKTamara B Harris - Laboratory of Epidemiology and Population Sciences, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USAAndrew T Hattersley - Institute of Biomedical and Clinical Science, University of Exeter, Exeter, UKAndrew C Heath - Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USAChristian Hengstenberg - 1] DZHK (Deutsches Forschungszentrum für Herz-Kreislauferkrankungen-German Research Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany. Deutsches Herzzentrum München, Technische Universität München, Munich, GermanyAndrew A Hicks - Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck, Lübeck, Germany)Lucia A Hindorff - Division of Genomic Medicine, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USAAroon D Hingorani - Institute of Cardiovascular Science, University College London, London, UKAlbert Hofman - 1] Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands. Department of Epidemiology, Erasmus Medical Center, Rotterdam, the NetherlandsG Kees Hovingh - Department of Vascular Medicine, Academic Medical Center, Amsterdam, the NetherlandsSteve E Humphries - Centre for Cardiovascular Genetics, Institute of Cardiovascular Sciences, University College London, London, UKSteven C Hunt - Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USAElina Hypponen - 1] School of Population Health, University of South Australia, Adelaide, South Australia, Australia. Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia. South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia. Centre for Paediatric Epidemiology and Biostatistics, University College London Institute of Child Health, London, UKKevin B Jacobs - 1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA. Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USAMarjo-Riitta Jarvelin - 1] Department of Epidemiology and Biostatistics, Imperial College London, London, UK. National Institute for Health and Welfare, Oulu, Finland. MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK. Unit of Primary Care, Oulu University Hospital, Oulu, Finland. Biocenter Oulu, University of Oulu, Oulu, Finland. Institute of Health Sciences, University of Oulu, Oulu, FinlandLu Qi - 1] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USAOlli T Raitakari - 1] Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, FinlandTuomo Rankinen - Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USAD C Rao - 1] Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA. Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA. Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USATreva K Rice - 1] Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA. Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USAMarylyn Ritchie - Center for Systems Genomics, Pennsylvania State University, University Park, Pennsylvania, USAIgor Rudan - 1] Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK. Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, CroatiaVeikko Salomaa - National Institute for Health and Welfare, Helsinki, FinlandNilesh J Samani - 1] Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK. National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UKJouko Saramies - South Carelia Central Hospital, Lappeenranta, FinlandMark A Sarzynski - Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USAPeter E H Schwarz - 1] Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Dresden, GermanySylvain Sebert - Institute of Health Sciences, University of Oulu, Oulu, FinlandPeter Sever - International Centre for Circulatory Health, Imperial College London, London, UKAlan R Shuldiner - 1] Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA. Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA. Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, Maryland, USAJuha Sinisalo - Helsinki University Central Hospital Heart and Lung Center, Department of Medicine, Helsinki University Central Hospital, Helsinki, FinlandValgerdur Steinthorsdottir - deCODE Genetics, Amgen, Inc., Reykjavik, IcelandRonald P Stolk - Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsJean-Claude Tardif - 1] Montreal Heart Institute, Montreal, Quebec, Canada. Montreal Heart Institute, Université de Montréal, Montreal, Quebec, CanadaAnke Tönjes - 1] Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany. Department of Medicine, University of Leipzig, Leipzig, GermanyAngelo Tremblay - Department of Kinesiology, Laval University, Quebec City, Quebec, CanadaElena Tremoli - Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano and Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, ItalyJarmo Virtamo - National Institute for Health and Welfare, Helsinki, FinlandMarie-Claude Vohl - 1] Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada. Department of Food Science and Nutrition, Laval University, Quebec City, Quebec, CanadaPhilippe Amouyel - Institut Pasteur de Lille, INSERM U744, Université de Lille 2, Lille, FranceFolkert W Asselbergs - 1] Institute of Cardiovascular Science, University College London, London, UK. Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands. Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, Utrecht, the NetherlandsThemistocles L Assimes - Department of Medicine, Stanford University School of Medicine, Stanford, California, USAMurielle Bochud - 1] Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland. Ministry of Health, Victoria, Republic of SeychellesBernhard O Boehm - 1] Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, Ulm, Germany. Lee Kong Chian School of Medicine, Imperial College London and Nanyang Technological University, SingaporeEric Boerwinkle - Health Science Center at Houston, University of Texas, Houston, Texas, USAErwin P Bottinger - Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USAClaude Bouchard - Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USAStéphane Cauchi - 1] CNRS UMR 8199, Lille, France. European Genomic Institute for Diabetes, Lille, France. Université de Lille 2, Lille, FranceJohn C Chambers - 1] Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK. Department of Epidemiology and Biostatistics, Imperial College London, London, UK. Imperial College Healthcare NHS Trust, London, UKStephen J Chanock - Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USARichard S Cooper - Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois, USAPaul I W de Bakker - 1] Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands. Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Department of Epidemiology, University Medical Center Utrecht, Utrecht, the NetherlandsGeorge Dedoussis - Department of Dietetics-Nutrition, Harokopio University, Athens, GreeceLuigi Ferrucci - Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, USAPaul W Franks - 1] Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA. Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hospital, Malmö, Sweden. Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, SwedenPhilippe Froguel - 1] Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK. CNRS UMR 8199, Lille, France. European Genomic Institute for Diabetes, Lille, France. Université de Lille 2, Lille, FranceLeif C Groop - 1] Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland. Lund University Diabetes Centre, Lund University, Malmö, Sweden. Diabetes and Endocrinology Unit, Department of Clinical Science, Lund University, Malmö, SwedenChristopher A Haiman - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USAAnders Hamsten - Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, SwedenM Geoffrey Hayes - Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USAJennie Hui - 1] PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia, Australia. Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia. School of Population Health, University of South Australia, Adelaide, South Australia, Australia. Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, AustraliaDavid J Hunter - 1] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA. Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USAKristian Hveem - Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, NorwayJ Wouter Jukema - 1] Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, Utrecht, the Netherlands. Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, the NetherlandsRobert C Kaplan - Department of Epidemiology and Population Health, Albert Einstein College of Medicine. Belfer, New York, USAMika Kivimaki - Department of Epidemiology and Public Health, University College London, London, UKDiana Kuh - MRC Unit for Lifelong Health and Ageing at University College London, London, UKMarkku Laakso - Department of Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, FinlandYongmei Liu - Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USANicholas G Martin - QIMR Berghofer Medical Research Institute, Brisbane, Queensland, AustraliaWinfried März - 1] Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. Synlab Academy, Synlab Services, Mannheim, GermanyMads Melbye - 1] Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. Department of Medicine, Stanford University School of Medicine, Stanford, California, USASusanne Moebus - Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, GermanyPatricia B Munroe - 1] Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UKInger Njølstad - Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Tromsø, Tromsø, NorwayBen A Oostra - 1] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. Center for Medical Systems Biology, Leiden, the Netherlands. Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the NetherlandsColin N A Palmer - Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UKNancy L Pedersen - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenMarkus Perola - 1] Estonian Genome Center, University of Tartu, Tartu, Estonia. National Institute for Health and Welfare, Helsinki, Finland. Institute for Molecular Medicine, University of Helsinki, Helsinki, FinlandLouis Pérusse - 1] Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada. Department of Kinesiology, Laval University, Quebec City, Quebec, CanadaUlrike Peters - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USAJoseph E Powell - 1] Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, Queensland, AustraliaChris Power - Centre for Paediatric Epidemiology and Biostatistics, University College London Institute of Child Health, London, UKThomas Quertermous - Department of Medicine, Stanford University School of Medicine, Stanford, California, USARainer Rauramaa - 1] Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, FinlandEva Reinmaa - Estonian Genome Center, University of Tartu, Tartu, EstoniaPaul M Ridker - 1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. Harvard Medical School, Boston, Massachusetts, USAFernando Rivadeneira - 1] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands. Department of Epidemiology, Erasmus Medical Center, Rotterdam, the NetherlandsJerome I Rotter - Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-University of California, Los Angeles Medical Center, Torrance, California, USATimo E Saaristo - 1] Finnish Diabetes Association, Tampere, Finland. Pirkanmaa Hospital District, Tampere, FinlandDanish Saleheen - 1] Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Center for Non-Communicable Diseases, Karatchi, Pakistan. Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USADavid Schlessinger - Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USAP Eline Slagboom - 1] Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden, the Netherlands. Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the NetherlandsHarold Snieder - Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsTim D Spector - Department of Twin Research and Genetic Epidemiology, King's College London, London, UKKonstantin Strauch - 1] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians Universität, Neuherberg, GermanyMichael Stumvoll - 1] Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany. Department of Medicine, University of Leipzig, Leipzig, GermanyJaakko Tuomilehto - 1] National Institute for Health and Welfare, Helsinki, Finland. Instituto de Investigacion Sanitaria del Hospital Universario La Paz (IdiPAZ), Madrid, Spain. Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia. Centre for Vascular Prevention, Danube University Krems, Krems, AustriaMatti Uusitupa - 1] Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. Research Unit, Kuopio University Hospital, Kuopio, FinlandPim van der Harst - 1] Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, Utrecht, the NetherlandsHenry Völzke - 1] DZHK (Deutsches Zentrum für Herz-Kreislaufforschung-German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. Institute for Community Medicine, University Medicine Greifswald, Greifswald, GermanyMark Walker - Institute of Cellular Medicine, Newcastle University, Newcastle, UKNicholas J Wareham - Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UKHugh Watkins - 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, UKH-Erich Wichmann - 1] Chair of Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians Universität, Munich, Germany. Klinikum Großhadern, Munich, Germany. Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyJames F Wilson - Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UKPieter Zanen - Department of Pulmonology, University Medical Center Utrecht, Utrecht, the NetherlandsPanos Deloukas - 1] Wellcome Trust Sanger Institute, Hinxton, UK. William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. King Abdulaziz University, Jeddah, Saudi ArabiaIris M Heid - 1] Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany. Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, GermanyCecilia M Lindgren - 1] Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UKKaren L Mohlke - Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USAElizabeth K Speliotes - 1] Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USAUnnur Thorsteinsdottir - 1] deCODE Genetics, Amgen, Inc., Reykjavik, Iceland. Faculty of Medicine, University of Iceland, Reykjavik, IcelandInês Barroso - 1] Wellcome Trust Sanger Institute, Hinxton, UK. University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UKCaroline S Fox - National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, USAKari E North - 1] Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USADavid P Strachan - Division of Population Health Sciences and Education, St George's, University of London, London, UKJacques S Beckmann - 1] Swiss Institute of Bioinformatics, Lausanne, Switzerland. Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. Service of Medical Genetics, CHUV University Hospital, Lausanne, SwitzerlandSonja I Berndt - Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USAMichael Boehnke - Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USAIngrid B Borecki - Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USAMark I McCarthy - 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford, UKAndres Metspalu - 1] Estonian Genome Center, University of Tartu, Tartu, Estonia. Institute of Molecular and Cell Biology, University of Tartu, Tartu, EstoniaKari Stefansson - 1] deCODE Genetics, Amgen, Inc., Reykjavik, Iceland. Faculty of Medicine, University of Iceland, Reykjavik, IcelandAndré G Uitterlinden - 1] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands. Department of Epidemiology, Erasmus Medical Center, Rotterdam, the NetherlandsCornelia M van Duijn - 1] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands. Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. Center for Medical Systems Biology, Leiden, the NetherlandsLude Franke - Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsCristen J Willer - 1] Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA. Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USAAlkes L Price - 1] Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA. Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA. Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USAGuillaume Lettre - 1] Montreal Heart Institute, Montreal, Quebec, Canada. Montreal Heart Institute, Université de Montréal, Montreal, Quebec, CanadaRuth J F Loos - 1] Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USAMichael N Weedon - Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UKErik Ingelsson - 1] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UKJeffrey R O'Connell - 1] Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA. Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USAGoncalo R Abecasis - Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USADaniel I Chasman - 1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. Harvard Medical School, Boston, Massachusetts, USAMichael E Goddard - 1] Biosciences Research Division, Department of Primary Industries, Melbourne, Victoria, Australia. Department of Food and Agricultural Systems, University of Melbourne, Melbourne, Victoria, AustraliaPeter M Visscher - 1] Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, Queensland, AustraliaJoel N Hirschhorn - 1] Division of Endocrinology, Genetics and Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA. Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USATimothy M Frayling - Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK
- Resource Type
- Journal article
- Publication Details
- Nature genetics, Vol.46(11), pp.1173-1186
- DOI
- 10.1038/ng.3097
- PMID
- 25282103
- PMCID
- PMC4250049
- NLM abbreviation
- Nat Genet
- ISSN
- 1061-4036
- eISSN
- 1546-1718
- Publisher
- United States
- Grant note
- R01 HL087700 / NHLBI NIH HHS MR/L01629X/1 / Medical Research Council R01 DK072193 / NIDDK NIH HHS CZB/4/672 / Chief Scientist Office R01 HL109946 / NHLBI NIH HHS FS/12/33/29561 / British Heart Foundation 090532 / Wellcome Trust P30 CA071789 / NCI NIH HHS P30 HD018655 / NICHD NIH HHS RG/08/008/25291 / British Heart Foundation FS/14/12/30540 / British Heart Foundation FS/12/8/29377 / British Heart Foundation CZB/4/710 / Chief Scientist Office 323195 / European Research Council P30 GM103341 / NIGMS NIH HHS R01 HL088215 / NHLBI NIH HHS R01 HL117626 / NHLBI NIH HHS PG/07/085/23349 / British Heart Foundation MC_UU_12015/1 / Medical Research Council MC_U106179472 / Medical Research Council P01 GM099568 / NIGMS NIH HHS MR/K006584/1 / Medical Research Council R25 GM062459 / NIGMS NIH HHS MC_UU_12015/2 / Medical Research Council MR/K013351/1 / Medical Research Council P30 DK072488 / NIDDK NIH HHS U01 HG007419 / NHGRI NIH HHS MC_PC_U127561128 / Medical Research Council RP-PG-0310-1002 / Department of Health T32 HL007055 / NHLBI NIH HHS G0601463 / Medical Research Council U01 CA164930 / NCI NIH HHS P30 DK063491 / NIDDK NIH HHS RG/10/12/28456 / British Heart Foundation MC_UU_12015/5 / Medical Research Council P30 CA015704 / NCI NIH HHS 085301 / Wellcome Trust R01 GM075091 / NIGMS NIH HHS G0500070 / Medical Research Council RG/09/012/28096 / British Heart Foundation MC_U106179471 / Medical Research Council RG/08/014/24067 / British Heart Foundation 098395 / Wellcome Trust SP/08/002/24118 / British Heart Foundation UL1 TR000124 / NCATS NIH HHS MC_UU_12019/1 / Medical Research Council R01 DK093757 / NIDDK NIH HHS MR/L003120/1 / Medical Research Council MC_UP_A100_1003 / Medical Research Council R01 DK075787 / NIDDK NIH HHS U01 DK062370 / NIDDK NIH HHS 098381 / Wellcome Trust FS/11/35/28871 / British Heart Foundation T32 GM080178 / NIGMS NIH HHS G1002084 / Medical Research Council
- Language
- English
- Date published
- 11/2014
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025411602771
Metrics
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