Definitions of Pediatric Pancreatitis and Survey of Present Clinical Practices

Veronique D MORINVILLE; Sohail Z HUSAIN; Steven WERLIN; Michael WILSCHANSKI; Aliye UC; Harrison BAI; Bradley BARTH; Rabea ALHOSH; Peter R DURIE; Steven D FREEDMAN; Ryan HIMES; Mark E LOWE; John POHL

doi:10.1097/MPG.0b013e31824f1516

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Definitions of Pediatric Pancreatitis and Survey of Present Clinical Practices

Journal article

Open access

Peer reviewed

Definitions of Pediatric Pancreatitis and Survey of Present Clinical Practices

Veronique D MORINVILLE, Sohail Z HUSAIN, Steven WERLIN, Michael WILSCHANSKI, Aliye UC, Harrison BAI, Bradley BARTH, Rabea ALHOSH, Peter R DURIE, Steven D FREEDMAN, …

Journal of pediatric gastroenterology and nutrition, Vol.55(3), pp.261-265

2012

DOI: 10.1097/MPG.0b013e31824f1516

PMID: 22357117

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https://www.ncbi.nlm.nih.gov/pmc/articles/3626452View

Open Access

Abstract

Objectives: There is limited literature on acute pancreatitis (AP), acute recurrent pancreatitis (ARP), and chronic pancreatitis (CP) in children. The International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE) consortium was formed to standardize definitions, develop diagnostic algorithms, investigate disease pathophysiology, and design prospective multicenter studies in pediatric pancreatitis. Methods: Subcommittees were formed to delineate definitions of pancreatitis, and a survey was conducted to analyze present practice. Results: AP was defined as requiring 2 of the following: abdominal pain compatible with AP, serum amylase and/or lipase values ≥3 times upper limits of normal, and imaging findings of AP. ARP was defined as ≥2 distinct episodes of AP with intervening return to baseline. CP was diagnosed in the presence of typical abdominal pain plus characteristic imaging findings, or exocrine insufficiency plus imaging findings, or endocrine insufficiency plus imaging findings. We found that children with pancreatitis were primarily managed by pediatric gastroenterologists. Unless the etiology was known, initial investigations included serum liver enzymes, triglycerides, calcium, and abdominal ultrasound. Further investigations (usually for ARP and CP) included magnetic resonance or other imaging, sweat chloride, and genetic testing. Respondents' future goals for INSPPIRE included determining natural history of pancreatitis, developing algorithms to evaluate and manage pancreatitis, and validating diagnostic criteria. Conclusions: INSPPIRE represents the first initiative to create a multicenter approach to systematically characterize pancreatitis in children. Future aims include creation of patient database and biologic sample repository.

Fundamental and applied biological sciences. Psychology

Feeding. Feeding behavior

Gastroenterology. Liver. Pancreas. Abdomen

Vertebrates: anatomy and physiology, studies on body, several organs or systems

Liver. Biliary tract. Portal circulation. Exocrine pancreas

Biological and medical sciences

Medical sciences

Other diseases. Semiology

Details

Title: Subtitle: Definitions of Pediatric Pancreatitis and Survey of Present Clinical Practices
Creators: Veronique D MORINVILLE - Division of Pediatric Gastroenterology and Nutrition, Montreal Children's Hospital, McGill University, Montreal, Canada
Sohail Z HUSAIN - Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Pittsburgh, Pittsburgh, PA, United States
Steven WERLIN - Medical College of Wisconsin, Milwaukee, WI, United States
Michael WILSCHANSKI - Hadassah University Hospitals, Jerusalem, Israel
Aliye UC - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, United States
Harrison BAI - Department of Pediatrics, Yale University School of Medicine, New Haven, CT, United States
Bradley BARTH - Department of Pediatrics, University of Texas South-western Medical School, Dallas, TX, United States
Rabea ALHOSH - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, United States
Peter R DURIE - Department of Pediatrics, Hospital for Sick Children, Toronto, Canada
Steven D FREEDMAN - Department of Medicine, Harvard Medical School, Boston, MA, United States
Ryan HIMES - Baylor College of Medicine, Houston, TX, United States
Mark E LOWE - Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Pittsburgh, Pittsburgh, PA, United States
John POHL - University of Utah, Salt Lake City, UT, United States
Resource Type: Journal article
Publication Details: Journal of pediatric gastroenterology and nutrition, Vol.55(3), pp.261-265
DOI: 10.1097/MPG.0b013e31824f1516
PMID: 22357117
NLM abbreviation: J Pediatr Gastroenterol Nutr
ISSN: 0277-2116
eISSN: 1536-4801
Publisher: Lippincott Williams & Wilkins; Hagerstown, MD
Language: English
Date published: 2012
Academic Unit: Stead Family Department of Pediatrics; Radiation Oncology; Gastroenterology, Hepatology, Pancreatology, and Nutrition
Record Identifier: 9984047883702771

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