Journal article
Deformable Biomechanics of DMEK Tissue Scrolls Traveling Through Narrow Lumens: The Inverse Relationships Between Fluid Velocity, Scroll Width, and Wall Contact and Their Clinical Implications for Preloading
Cornea, Vol.43(6), pp.757-763
06/2024
DOI: 10.1097/ICO.0000000000003441
PMID: 38016012
Abstract
PURPOSE The aim of this study was to evaluate Descemet membrane endothelial keratoplasty (DMEK) scroll width and length in relation to variable velocities as the tissue transits through wide and narrow lumen glass tubes. METHODS Sets of DMEK tissue were processed using the Iowa Lions Eye Bank standard DMEK protocol and were passed through 2 glass tube widths at variable speeds. Two hourglass-shaped glass tubes were created, one "wide" and one "narrow." A syringe pump, valve, and pressure gauge were used to modulate tissue speed through each tube. For both tube sizes, DMEK tissue was passed through their lumens with incrementally increasing velocity and visualized with a high-speed camera at frame rates from 1000 to 8000 fps. Scroll width and length were measured using IDT Motion Studio software and digital calipers. RESULTS There was a significant, indirect correlation between scroll velocity and width in both the wide (R2 = -0.98, P < 0.001) and narrow (R2 = -0.84, P < 0.001) tubes. There was a significant, direct correlation between scroll velocity and length in both the wide (R2 = 0.84, P < 0.001) and narrow (R2 = 0.83, P < 0.001) tubes. The resting widths of the scrolls were 105% and 207% wider than the wide and narrow tubes, respectively. All transits recorded scroll widths that were equal to or smaller than their respective tube's internal diameter. CONCLUSIONS There is a significant, inverse correlation between DMEK scroll velocity and width as well as a direct correlation between scroll velocity and length, allowing DMEK scrolls to transit through a tube that is narrower than its resting width without sustained lumen wall contact.
Details
- Title: Subtitle
- Deformable Biomechanics of DMEK Tissue Scrolls Traveling Through Narrow Lumens: The Inverse Relationships Between Fluid Velocity, Scroll Width, and Wall Contact and Their Clinical Implications for Preloading
- Creators
- Matthew Kigin - University of IowaBenjamin Revis - University of IowaSarah Vigmostad - University of IowaChristopher Sales - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Cornea, Vol.43(6), pp.757-763
- DOI
- 10.1097/ICO.0000000000003441
- PMID
- 38016012
- eISSN
- 1536-4798
- Grant note
- DOI: 10.13039/100015515, name: Roy J. and Lucille A. Carver College of Medicine, University of Iowa
- Language
- English
- Electronic publication date
- 11/28/2023
- Date published
- 06/2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Mechanical Engineering; Ophthalmology and Visual Sciences
- Record Identifier
- 9984521373002771
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