Journal article
Deformable Biomechanics of DMEK Tissue Scrolls Traveling Through Narrow Lumens II: Double Scrolls Do Not Behave Like Single Scrolls
Cornea, Vol.44(7), pp.916-920
07/2025
DOI: 10.1097/ICO.0000000000003830
PMID: 39937050
Abstract
To investigate and compare the dimensional characteristics of Descemet membrane endothelial keratoplasty (DMEK) scrolls in single-scroll and double-scroll conformations at various ages and velocities.
DMEK tissues from three donor pairs (ages 47, 62, and 69) were used to compare single-scroll and double-scroll widths under different velocities. Tissues were randomized and manipulated into single-scroll or double-scroll conformation using a syringe pump connected to an hourglass-shaped glass tube. All scrolls were passed through the tube at three different velocities set by syringe pump settings, and high-speed videography at 2000 frames per second captured scroll dimensions. Scroll dimensions were measured using IDT Motion Studio software.
Single-scrolled DMEK tissue was narrower than double-scrolled tissue across all donor ages. Double-scrolled tissue width remained relatively unchanged regardless of age or velocity. Significant differences in scroll width between single and double scrolls were observed in the 47-year-old donor tissue at all velocities (P <0.001). Significant scroll width differences between single and double scrolls were observed in the 62-year-old donor tissue at medium and high velocities (P = 0.03 and P = 0.01, respectively). In the 69-year-old donor tissue, significant differences in scroll width between single and double scrolls were observed only at high velocities (P = 0.003). Single-scroll width decreased with increasing velocity for 47-year-old and 62-year-old donor tissues (P <0.001, P = 0.03), but not for the 69-year-old donor tissue (P = 1.0).
There is a significant difference in scroll width between single-scrolled and double-scrolled tissues at high speeds. These differences become less significant as scrolls increase in age and velocity decreases.
Details
- Title: Subtitle
- Deformable Biomechanics of DMEK Tissue Scrolls Traveling Through Narrow Lumens II: Double Scrolls Do Not Behave Like Single Scrolls
- Creators
- Matthew Kigin - University of IowaEvan Balk - University of Iowa, Stead Family Department of PediatricsBenjamin Revis - University of IowaSarah Vigmostad - University of IowaChristopher Sales - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Cornea, Vol.44(7), pp.916-920
- DOI
- 10.1097/ICO.0000000000003830
- PMID
- 39937050
- NLM abbreviation
- Cornea
- ISSN
- 1536-4798
- eISSN
- 1536-4798
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Language
- English
- Electronic publication date
- 02/11/2025
- Date published
- 07/2025
- Academic Unit
- Stead Family Department of Pediatrics; Engineering Administration; Mechanical Engineering; Ophthalmology and Visual Sciences
- Record Identifier
- 9984791079002771
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