Journal article
Degenerate antigen recognition by CD4 + effector T cells in experimental autoimmune encephalomyelitis
Journal of neuroimmunology, Vol.75(1), pp.156-162
1997
DOI: 10.1016/S0165-5728(97)00014-3
PMID: 9143249
Abstract
Peptide-specific tolerance with PLP139–151 peptide analogs was used to compare the fine antigen-specificity requirements at both the inductive and effector phases of relapsing EAE (R-EAE). A PLP139–151 analog peptide containing a single substitution at the primary T cell receptor (TcR) contact residue (A144) did not induce proliferation in PLP139–151-primed CD4
+ T cells. In addition, tolerance induced with ECDI-treated, A144-coupled splenocytes failed to prevent the inductive phase of PLP139–151-induced R-EAE or to inhibit the induction of peptide-specific DTH indicating that naive PLP139–151-specific T cells do not react with the A144 peptide analog. In contrast, A144-coupled splenocytes did prevent the expression of the effector phase of R-EAE and inhibited the elicitation of peptide-specific DTH responses upon administration to mice seven days
after immunization with PLP139–151. The results provide in vivo evidence that `antigen-experienced' T cells recognize a broader repertoire of antigens than do naive T cells and have important implications for the regulation of immune responses and for advancing our understanding of the pathogenesis and treatment of autoimmune disease.
Details
- Title: Subtitle
- Degenerate antigen recognition by CD4 + effector T cells in experimental autoimmune encephalomyelitis
- Creators
- Bradford L McRaeNitin J KarandikarStephen D Miller
- Resource Type
- Journal article
- Publication Details
- Journal of neuroimmunology, Vol.75(1), pp.156-162
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0165-5728(97)00014-3
- PMID
- 9143249
- ISSN
- 0165-5728
- eISSN
- 1872-8421
- Language
- English
- Date published
- 1997
- Academic Unit
- Pathology
- Record Identifier
- 9984047883802771
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