Journal article
Degree of Risk of Bias in Randomized Controlled Trials: Does It Have an Impact on Root Coverage Outcomes?
The journal of evidence-based dental practice, Vol.21(1), pp.101526-101526
03/2021
DOI: 10.1016/j.jebdp.2021.101526
PMID: 34051960
Abstract
Improvement over time in mean (MRC) and complete root coverage (CRC) reported in randomized controlled trials (RCTs) has been documented. Our objective was to assess the effect that the ROB has on relevant outcomes reported in RCTs evaluating the efficacy of a commonly performed root coverage procedure.
RCTs that involved the use of a bilaminar technique of coronally advanced flap with connective tissue graft were selected. The following data were extracted: MRC, CRC, whether conflict of interest was addressed (yes/no), adequacy of random sequence generation, allocation concealment, and blinding of outcome assessment. Trials were categorized into four groups as per different time periods: before Consolidated Standards of Reporting Trials (CONSORT) (before 1996), CONSORT (1997 to 2001), CONSORT 2001 (2002 to 2010), and CONSORT 2010 (2011 to 2019). Differences between group means were assessed using statistical analyses.
The search yielded a total of 47 RCTs published between 1993 and 2019 that met the inclusion criteria. A trend toward lower ROB over time in the selected RCTs was observed. However, differences in MRC and CRC with respect to the degree ROB of included trials were not significant.
Degree of ROB did not influence MRC and CRC reported in the RCTs included in this investigation. This finding suggests that the observed improvement of clinical outcomes over time should be attributed to other factors, such as refinement of surgical techniques.
•Forty-seven randomized controlled trials (RCTs) on root coverage procedure published between 1993 and 2019 that met the inclusion criteria were included.•A trend towards lower risk of bias over time in the selected RCTs was observed.•Degree of ROB did not influence root coverage outcomes reported in the RCTs included in this investigation.
Details
- Title: Subtitle
- Degree of Risk of Bias in Randomized Controlled Trials: Does It Have an Impact on Root Coverage Outcomes?
- Creators
- Mustafa Tattan - University of IowaKatherine S Moore - University of IowaLeandro Chambrone - University of IowaGustavo Avila-Ortiz - University of IowaSatheesh Elangovan - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The journal of evidence-based dental practice, Vol.21(1), pp.101526-101526
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.jebdp.2021.101526
- PMID
- 34051960
- ISSN
- 1532-3382
- eISSN
- 1532-3390
- Language
- English
- Date published
- 03/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Periodontics
- Record Identifier
- 9984201525802771
Metrics
12 Record Views