Journal article
Delayed administration of recombinant human parathyroid hormone improves early biomechanical strength in a rat rotator cuff repair model
Journal of shoulder and elbow surgery, Vol.25(8), pp.1280-1287
08/2016
DOI: 10.1016/j.jse.2015.12.016
PMID: 26948004
Abstract
Despite advances in intraoperative techniques, rotator cuff repairs frequently do not heal. Recombinant human parathyroid hormone (rhPTH) has been shown to improve healing at the tendon-to-bone interface in an established acute rat rotator cuff repair model. We hypothesized that administration of rhPTH beginning on postoperative day 7 would result in improved early load to failure after acute rotator cuff repair in an established rat model.
Acute rotator cuff repairs were performed in 108 male Sprague-Dawley rats. Fifty-four rats received daily injections of rhPTH beginning on postoperative day 7 until euthanasia or a maximum of 12 weeks postoperatively. The remaining 54 rats received no injections and served as the control group. Animals were euthanized at 2 and 16 weeks postoperatively and evaluated by gross inspection, biomechanical testing, and histologic analysis.
At 2 weeks postoperatively, rats treated with rhPTH demonstrated significantly higher load to failure than controls (10.9 vs. 5.2 N; P = .003). No difference in load to failure was found between the 2 groups at 16 weeks postoperatively, although control repairs more frequently failed at the tendon-to-bone interface (45.5% vs. 22.7%; P = .111). Blood vessel density appeared equivalent between the 2 groups at both time points, but increased intracellular and extracellular vascular endothelial growth factor expression was noted in the rhPTH-treated group at 2 weeks.
Delayed daily administration of rhPTH resulted in increased early load to failure and equivalent blood vessel density in an acute rotator cuff repair model.
Details
- Title: Subtitle
- Delayed administration of recombinant human parathyroid hormone improves early biomechanical strength in a rat rotator cuff repair model
- Creators
- Kyle R Duchman - Department of Orthopaedics & Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: kyle-duchman@uiowa.eduJessica E Goetz - Department of Orthopaedics & Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA, USABastian U Uribe - Department of Orthopaedics & Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA, USAAndrew M Amendola - Department of Orthopaedics & Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA, USAJoshua A Barber - Department of Orthopaedics & Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA, USAAllison E Malandra - Department of Orthopaedics & Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA, USADouglas C Fredericks - Department of Orthopaedics & Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA, USACarolyn M Hettrich - Department of Orthopaedics & Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Journal of shoulder and elbow surgery, Vol.25(8), pp.1280-1287
- DOI
- 10.1016/j.jse.2015.12.016
- PMID
- 26948004
- NLM abbreviation
- J Shoulder Elbow Surg
- ISSN
- 1058-2746
- eISSN
- 1532-6500
- Publisher
- United States
- Language
- English
- Date published
- 08/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center
- Record Identifier
- 9984040340302771
Metrics
26 Record Views