Journal article
Delayed potassium current and non-specific outward current in pyramidal neurones acutely dissociated from rat hippocampus
Brain research, Vol.568(1), pp.350-354
1991
DOI: 10.1016/0006-8993(91)91425-Z
PMID: 1814580
Abstract
The electrical property of delayed K
+ currents (I
KD) was studied in pyramidal neurones freshly isolated from the rat hippocampal CA1 region. TheI
KD was separated pharmacologically from other membrane currents. Activation and inactivation processes of theI
KD were highly voltage-dependent in the potential range between −30 and +20 mV. The steady-state inactivation ofI
KD was observed at −100 mV or more positive potentials. The potential for half steady-state inactivation was −65mV. TheI
KD was fully inactivated around −20 mV. Reactivation ofI
KD consisted of two exponential components. After pharmacological suppression ofI
KD, the small amount of residual voltage-dependent outward current (one-fifteenth to one-twentieth ofI
KD amplitude) was observed. The current kinetics was similar to that ofI
KD and greatly reduced by substitution of internal K
+ withN-methyl-
d-glucamine
+. It was concluded that the properties ofI
KD was basically similar to those ofI
KD in other excitable tissues and that the residual current might be non-specific outward current.
Details
- Title: Subtitle
- Delayed potassium current and non-specific outward current in pyramidal neurones acutely dissociated from rat hippocampus
- Creators
- Yasuo Oyama - Department of Neurophysiology, Tohoku University School of Medicine, Sendai JapanNobutoshi Harata - Department of Neurophysiology, Tohoku University School of Medicine, Sendai JapanNorio Akaike - Department of Neurophysiology, Tohoku University School of Medicine, Sendai Japan
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.568(1), pp.350-354
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0006-8993(91)91425-Z
- PMID
- 1814580
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1991
- Academic Unit
- Molecular Physiology and Biophysics
- Record Identifier
- 9984025573202771
Metrics
17 Record Views