Deletion of the voltage-gated calcium channel, Ca V 1.3, causes deficits in motor performance and associative learning

Marisol Lauffer; Hsiang Wen; Bryn Myers; Ashley Plumb; Krystal Parker; Aislinn Williams

doi:10.1111/gbb.12791

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Deletion of the voltage-gated calcium channel, Ca V 1.3, causes deficits in motor performance and associative learning

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Deletion of the voltage-gated calcium channel, Ca V 1.3, causes deficits in motor performance and associative learning

Marisol Lauffer, Hsiang Wen, Bryn Myers, Ashley Plumb, Krystal Parker and Aislinn Williams

Genes, brain and behavior, Vol.21(2), e12791

01/19/2022

DOI: 10.1111/gbb.12791

PMCID: PMC9744532

PMID: 35044095

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Abstract

L-type voltage-gated calcium channels are important regulators of neuronal activity and are widely expressed throughout the brain. One of the major L-type voltage-gated calcium channel isoforms in the brain is Ca 1.3. Mice lacking Ca 1.3 are reported to have impairments in fear conditioning and depressive-like behaviors, which have been linked to Ca 1.3 function in the hippocampus and amygdala. Genetic variation in Ca 1.3 has been linked to a variety of psychiatric disorders, including autism and schizophrenia, which are associated with altered motor learning, associative learning and social function. Here, we explored whether Ca 1.3 plays a role in these behaviors. We found that Ca 1.3 knockout mice have deficits in rotarod learning despite normal locomotor function. Deletion of Ca 1.3 is also associated with impaired gait adaptation and associative learning on the Erasmus Ladder. We did not observe any impairments in Ca 1.3 knockout mice on assays of anxiety-like, depression-like or social preference behaviors. Our results suggest an important role for Ca 1.3 in neural circuits involved in motor learning and concur with previous data showing its involvement in associative learning.

behavioral genetics

motor learning

Cacna1d

motor behavior

calcium channels

L-type channel

Erasmus Ladder

learning

rotarod

knockout mouse

Details

Title: Subtitle: Deletion of the voltage-gated calcium channel, Ca V 1.3, causes deficits in motor performance and associative learning
Creators: Marisol Lauffer - Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa, USA
Hsiang Wen - Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
Bryn Myers - Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
Ashley Plumb - Department of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, Iowa, USA
Krystal Parker - Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
Aislinn Williams - Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
Resource Type: Journal article
Publication Details: Genes, brain and behavior, Vol.21(2), e12791
DOI: 10.1111/gbb.12791
PMID: 35044095
PMCID: PMC9744532
NLM abbreviation: Genes Brain Behav
eISSN: 1601-183X
Grant note: KL2TR002536 / NCATS NIH HHS The University of Iowa Carver College of Medicine R01MH118240 / NIMH NIH HHS Roy J. Carver Charitable Trust University of Iowa Graduate Program in Neuroscience K01MH106824 / NIMH NIH HHS
Language: English
Date published: 01/19/2022
Academic Unit: Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Physical Therapy and Rehabilitation Science
Record Identifier: 9984209495602771

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