Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Madhavi Rangaswamy; Kevin A Jones; Bernice Porjesz; David B Chorlian; Ajayan Padmanabhapillai; Chella Kamarajan; Samuel Kuperman; John Rohrbaugh; Sean J O'Connor; Lance O Bauer; Marc A Schuckit; Henri Begleiter

doi:10.1016/j.ijpsycho.2006.10.003

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Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Journal article

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Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Madhavi Rangaswamy, Kevin A Jones, Bernice Porjesz, David B Chorlian, Ajayan Padmanabhapillai, Chella Kamarajan, Samuel Kuperman, John Rohrbaugh, Sean J O'Connor, Lance O Bauer, …

International journal of psychophysiology, Vol.63(1), pp.3-15

2007

DOI: 10.1016/j.ijpsycho.2006.10.003

PMID: 17129626

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http://doi.org/10.1016/j.ijpsycho.2006.10.00View

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Abstract

Visual P300 is consistently lower in alcohol-dependent individuals, their offspring and subjects at risk. Delta and theta event-related oscillations (ERO) are the major contributors to the P300 signal. The total and evoked power in delta and theta bands in the 300 to 700 ms post-stimulus window (corresponding to the zone of P300 maxima) was compared between adolescent offspring of alcoholics (high-risk) and age-matched normal controls (low-risk), to assess the utility of the risk markers. EEG was recorded during the performance of a visual oddball task. The S-transform algorithm decomposed the EEG signals into different frequency bands and the group differences in total and evoked power in the oscillatory responses during the P300 time window (300 to 700 ms) were analyzed using a multivariate design. Similar analysis was performed on P300 peak amplitude for the target. The high-risk group showed significantly lower parietal post-stimulus evoked and total power in the delta band for targets. A decrease in total power was seen centrally and parietally in the theta band. The P300 peak amplitude in the parietal electrodes was also significantly lower in the high-risk group. The decreased total theta power and total and evoked delta power for visual targets in high risk individuals may serve as an endophenotypic marker in the development of alcoholism and other disinhibitory disorders. The differences seen between the offspring of alcoholics and controls may have a cholinergic basis. The ERO measures appear to be more robust than the P300 amplitude in differentiating the groups.

Highrisk

Theta oscillation

Alcoholism

P300

Adolescent

Endophenotype

Details

Title: Subtitle: Delta and theta oscillations as risk markers in adolescent offspring of alcoholics
Creators: Madhavi Rangaswamy - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, NY 11203, USA
Kevin A Jones - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, NY 11203, USA
Bernice Porjesz - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, NY 11203, USA
David B Chorlian - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, NY 11203, USA
Ajayan Padmanabhapillai - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, NY 11203, USA
Chella Kamarajan - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, NY 11203, USA
Samuel Kuperman - University of Iowa Hospitals, Division of Child Psychiatry, Iowa City, IA 52242, USA
John Rohrbaugh - Washington University – Division of Family Studies, St. Louis, MO 63108, USA
Sean J O'Connor - Department of Psychiatry, Institute of Psychiatric Research, Indiana University Medical Center, Indianapolis, IN 46202, USA
Lance O Bauer - University of Connecticut Health Center, Department of Psychiatry, Farmington, CT 06030, USA
Marc A Schuckit - Department of Psychiatry (116A), University of California, San Diego and San Diego Veterans Healthcare System, 3350 La Jolla Village Dr., San Diego, CA 92161-2002, USA
Henri Begleiter - Department of Psychiatry, State University of New York, Health Science Center at Brooklyn, NY 11203, USA
Resource Type: Journal article
Publication Details: International journal of psychophysiology, Vol.63(1), pp.3-15
DOI: 10.1016/j.ijpsycho.2006.10.003
PMID: 17129626
NLM abbreviation: Int J Psychophysiol
ISSN: 0167-8760
eISSN: 1872-7697
Publisher: Elsevier B.V
Language: English
Date published: 2007
Academic Unit: Psychiatry; Stead Family Department of Pediatrics
Record Identifier: 9984003425602771

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