Dementia outcomes after addition of proxy-based assessments for deceased or proxy-dependent participants

Sarah A Gaussoin; Mark A Espeland; Daniel P Beavers; Ramon Casanova; Katelyn R Garcia; Beverly M Snively; Sally A Shumaker; Robert B Wallace; Stephen R Rapp

doi:10.1002/gps.5130

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Dementia outcomes after addition of proxy-based assessments for deceased or proxy-dependent participants

Journal article

Open access

Peer reviewed

Dementia outcomes after addition of proxy-based assessments for deceased or proxy-dependent participants

Sarah A Gaussoin, Mark A Espeland, Daniel P Beavers, Ramon Casanova, Katelyn R Garcia, Beverly M Snively, Sally A Shumaker, Robert B Wallace and Stephen R Rapp

International journal of geriatric psychiatry, Vol.34(10), pp.1403-1411

10/2019

DOI: 10.1002/gps.5130

PMCID: PMC6742525

PMID: 31034676

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https://www.ncbi.nlm.nih.gov/pmc/articles/6742525View

Open Access

Abstract

As people age and the incidence of dementia increases, studies of cognitive function continue to be of importance. Ascertaining cognitive data through different mechanisms is necessary to address missing data concerns. The Dementia Questionnaire (DQ), which utilizes proxy-based assessments, is a potential tool to determine cognitive status in participants no longer being followed per traditional study protocol. The DQ is currently being used in the Supplemental Case Ascertainment Protocol (SCAP), which is being conducted in an ongoing study of postmenopausal women as part of the Women's Health Initiative Memory Study (WHIMS). Ninety-four percent of the 1260 SCAP participants were eligible because of being deceased. Those who are SCAP eligible were older, were less likely to be a minority, and were more likely to have hypertension, diabetes, and prior history of cardiovascular disease (CVD) as well as being a past or current smoker. SCAP added 109 cases of probable dementia to WHIMS. Risk factor relationships were modified upon inclusion of the SCAP cases including an attenuation of a hormone therapy effect and discovery of a hypertension effect. Augmenting clinic-based cases with proxy-based assessments is feasible and leads to increased incident cases of dementia. When planning future clinical trials, it may be of study benefit to include a protocol of proxy-based assessments, develop strong relationships with proxies early on in the study, and attempt to maintain this relationship throughout the lifespan of the trial.

Aged

Cognition - drug effects

Cognition - physiology

Cognition Disorders - diagnosis

Cognition Disorders - epidemiology

Cognition Disorders - prevention & control

Dementia - epidemiology

Female

Hormone Replacement Therapy - statistics & numerical data

Humans

Incidence

Middle Aged

Risk Factors

Surveys and Questionnaires - standards

Details

Title: Subtitle: Dementia outcomes after addition of proxy-based assessments for deceased or proxy-dependent participants
Creators: Sarah A Gaussoin - Department of Biostatistics and Data Science Wake Forest School of Medicine Winston‐Salem NC
Mark A Espeland - Department of Biostatistics and Data Science Wake Forest School of Medicine Winston‐Salem NC
Daniel P Beavers - Department of Biostatistics and Data Science Wake Forest School of Medicine Winston‐Salem NC
Ramon Casanova - Department of Biostatistics and Data Science Wake Forest School of Medicine Winston‐Salem NC
Katelyn R Garcia - Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC
Beverly M Snively - Department of Biostatistics and Data Science Wake Forest School of Medicine Winston‐Salem NC
Sally A Shumaker - Wake Forest University
Robert B Wallace - University of Iowa
Stephen R Rapp - Department of Social Sciences and Health Policy Wake Forest School of Medicine Winston‐Salem NC
Resource Type: Journal article
Publication Details: International journal of geriatric psychiatry, Vol.34(10), pp.1403-1411
DOI: 10.1002/gps.5130
PMID: 31034676
PMCID: PMC6742525
NLM abbreviation: Int J Geriatr Psychiatry
ISSN: 0885-6230
eISSN: 1099-1166
Grant note: HHSN268200464221C / U.S. Department of Health and Human Services HHSN271201100004C / NIA NIH HHS P30 AG049638 / NIA NIH HHS N01-WH-4-4221 / NHLBI NIH HHS
Language: English
Date published: 10/2019
Academic Unit: Epidemiology; Injury Prevention Research Center; Internal Medicine
Record Identifier: 9984363645202771

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